@article{59b4508f82f94fec8726529515bb4055,
title = "Imaging of tumor clones with differential liver colonization",
abstract = "We present a model of hepatic colorectal metastases which represents monoclonal cell lines double-labeled by luciferase and tdTomato. These cells form liver metastasis in varying numbers and patterns similar to those observed in patients. Using in vivo and ex vivo luminescent and fluorescent imaging we determine the growth kinetics and clonogenic frequency of tumor cells colonizing liver. Molecular profiling detected stable expressional differences between clones consistent with their phenotypes. The data indicate that clinically relevant phenotypes of liver metastases can be modeled in vivo.",
author = "Go Oshima and Wightman, {Sean C.} and Abhineet Uppal and Stack, {Melinda E.} and Pitroda, {Sean P.} and Oskvarek, {Jonathan J.} and Xiaona Huang and Posner, {Mitchell C.} and Samuel Hellman and Weichselbaum, {Ralph R.} and Khodarev, {Nikolai N.}",
note = "Funding Information: We thank Dr. Geoffrey L. Greene (University of Chicago) for the Luc2-tdTomato plasmid and HCT116 cell line, Mr. Ani Solanki (Animal Resource Center) for mice management and Dr. Lara Leoni for assistance with DLIT. This work was supported by the Virginia and D.K. Ludwig Fund for Cancer Research, Lung Cancer Research Foundation (LCRF) and Prostate Cancer Foundation (PCF). This work was supported in part by The Virginia and D.K. Ludwig Fund for Cancer Research, Lung Cancer Research Foundation (LCRF) and Prostate Cancer Foundation (PCF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",
year = "2015",
month = jun,
day = "22",
doi = "10.1038/srep10946",
language = "English (US)",
volume = "5",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}