TY - JOUR
T1 - ImmTher, a lipophilic disaccharide derivative of muramyl dipeptide, up- regulates specific monocyte cytokine genes and activates monocyte-mediated tumoricidal activity
AU - Worth, Laura L.
AU - Jia, Shu Fang
AU - An, Taeha
AU - Kleinerman, Eugenie S.
N1 - Funding Information:
Supported in part by CA-42992 (ESK) from the National Institutes of Health, by the Gillson Logenbaugh Foundation, and by core grant CA-16672
PY - 1999
Y1 - 1999
N2 - ImmTher, a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide, previously showed activity against liver and lung colorectal metastases in a phase I trial. The purpose of the current studies was to investigate whether ImmTher could up-regulate specific cytokine gene expression and protein production, as well as activate the tumoricidal or cytostatic activity of human monocytes. ImmTher induced the expression and production of interleukin(IL)-1α IL-1β, IL-6, IL-8, IL-12, macrophage chemotactic and activating factor, and tumor necrosis factor α but not IL-2 or IL-10. Cytostatic or cytotoxic monocyte activity was stimulated against human Ewing's sarcoma, osteosarcoma, and melanoma cells but not breast cancer cells. Production and secretion of these cytokine proteins may play a role in the antitumor activity of ImmTher.
AB - ImmTher, a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide, previously showed activity against liver and lung colorectal metastases in a phase I trial. The purpose of the current studies was to investigate whether ImmTher could up-regulate specific cytokine gene expression and protein production, as well as activate the tumoricidal or cytostatic activity of human monocytes. ImmTher induced the expression and production of interleukin(IL)-1α IL-1β, IL-6, IL-8, IL-12, macrophage chemotactic and activating factor, and tumor necrosis factor α but not IL-2 or IL-10. Cytostatic or cytotoxic monocyte activity was stimulated against human Ewing's sarcoma, osteosarcoma, and melanoma cells but not breast cancer cells. Production and secretion of these cytokine proteins may play a role in the antitumor activity of ImmTher.
KW - Cytokine activation
KW - ImmTher
KW - Immunotherapy
KW - Liposome- encapsulated
KW - Macrophage cytotoxicity
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U2 - 10.1007/s002620050580
DO - 10.1007/s002620050580
M3 - Article
C2 - 10473806
AN - SCOPUS:0032855210
SN - 0340-7004
VL - 48
SP - 312
EP - 320
JO - Cancer Immunology Immunotherapy
JF - Cancer Immunology Immunotherapy
IS - 6
ER -