Immune cells in pancreatic cancer: Joining the dark side

Yaqing Zhang; Florencia McAllister; Marina Pasca di Magliano

doi:10.4161/onci.29125

Immune cells in pancreatic cancer: Joining the dark side

Yaqing Zhang, Florencia McAllister, Marina Pasca di Magliano

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Pancreatic tumors are rich in immune cell infiltrates that include CD4⁺ T-cell subsets encompassing both regulatory T cells and T_H17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.

Original language	English (US)
Article number	e29125
Journal	OncoImmunology
Volume	3
Issue number	6
DOIs	https://doi.org/10.4161/onci.29125
State	Published - 2014
Externally published	Yes

Keywords

CD4 T cells
CD8 T cells
Il-17
Kras
Mouse model
Pancreatic cancer
Regulatory T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.29125

Cite this

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title = "Immune cells in pancreatic cancer: Joining the dark side",

abstract = "Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.",

keywords = "CD4 T cells, CD8 T cells, Il-17, Kras, Mouse model, Pancreatic cancer, Regulatory T cells",

author = "Yaqing Zhang and Florencia McAllister and {di Magliano}, {Marina Pasca}",

year = "2014",

doi = "10.4161/onci.29125",

language = "English (US)",

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journal = "OncoImmunology",

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TY - JOUR

T1 - Immune cells in pancreatic cancer

T2 - Joining the dark side

AU - Zhang, Yaqing

AU - McAllister, Florencia

AU - di Magliano, Marina Pasca

PY - 2014

Y1 - 2014

N2 - Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.

AB - Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.

KW - CD4 T cells

KW - CD8 T cells

KW - Il-17

KW - Kras

KW - Mouse model

KW - Pancreatic cancer

KW - Regulatory T cells

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U2 - 10.4161/onci.29125

DO - 10.4161/onci.29125

M3 - Article

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AN - SCOPUS:84906516245

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JO - OncoImmunology

JF - OncoImmunology

IS - 6

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ER -

Immune cells in pancreatic cancer: Joining the dark side

Abstract

Keywords

ASJC Scopus subject areas

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