Abstract
Aim: We aimed to quantify the effects of immune checkpoint inhibitors (ICIs) on the prognosis of COVID-19. Materials & methods: A meta-analysis was conducted and the hospitalization, severe disease and mortality rates were assessed. Thirteen studies comprising of 4614 cancer patients with COVID-19 were included. Results: When compared with cancer patients without prior ICI exposure, patients with prior ICI treatment exhibited a higher rate of hospitalization (odds ratio [OR] 2.0, 95% CI 1.19-3.38, p = 0.01). However, the OR of severe disease and mortality in ICI exposed cases was similar to non-ICI exposed patients (OR 1.55, 95% CI 0.69-3.51, p = 0.29; OR 1.12, 95% CI 0.85-1.48, p = 0.42, respectively). Conclusion: It is uncertain whether prior exposure to ICIs increases the risk of severe disease and death, however the observed OR suggest a higher rate of hospitalization.
Original language | English (US) |
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Pages (from-to) | 1271-1282 |
Number of pages | 12 |
Journal | Immunotherapy |
Volume | 13 |
Issue number | 15 |
DOIs | |
State | Published - Oct 2021 |
Keywords
- COVID-19
- hospitalization
- immune checkpoint inhibitor
- meta-analysis
- mortality
- prognosis
- severe disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology