TY - JOUR
T1 - Immune-induced cytopenia
T2 - bone marrow failure syndrome.
AU - Kondo, Yukio
AU - Molldrem, Jeffrey J.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2004/5
Y1 - 2004/5
N2 - Myelodysplastic syndromes, a heterogeneous group of clonal stem cell disorders, are characterized by ineffective and dysplastic hematopoiesis and increased risk of leukemic transformation. The clonal disorder may result in cumulative cytogenetic abnormalities in a multistep process. Intrinsic and extrinsic factors contributing to ineffective hematopoiesis include genetic predisposition, environmental effects, and iatrogenic causes. The common and often overlapping features of myelodysplastic syndrome, aplastic anemia, T-cell large granular lymphocyte lymphoproliferative disorder, and paroxysmal nocturnal hemoglobinuria suggest a shared pathophysiologic mechanism of marrow failure. Recent studies suggest that dominant clonal T cells, which may be driven to expand by hematopoietic antigenic stimuli, result in the T-cell-mediated inhibition of hematopoietic progenitors, thus contributing to cytopenia.
AB - Myelodysplastic syndromes, a heterogeneous group of clonal stem cell disorders, are characterized by ineffective and dysplastic hematopoiesis and increased risk of leukemic transformation. The clonal disorder may result in cumulative cytogenetic abnormalities in a multistep process. Intrinsic and extrinsic factors contributing to ineffective hematopoiesis include genetic predisposition, environmental effects, and iatrogenic causes. The common and often overlapping features of myelodysplastic syndrome, aplastic anemia, T-cell large granular lymphocyte lymphoproliferative disorder, and paroxysmal nocturnal hemoglobinuria suggest a shared pathophysiologic mechanism of marrow failure. Recent studies suggest that dominant clonal T cells, which may be driven to expand by hematopoietic antigenic stimuli, result in the T-cell-mediated inhibition of hematopoietic progenitors, thus contributing to cytopenia.
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M3 - Review article
C2 - 15087065
AN - SCOPUS:4544223504
SN - 1540-3408
VL - 3
SP - 178
EP - 183
JO - Current hematology reports
JF - Current hematology reports
IS - 3
ER -