Abstract
The authors report a case of severe dactinomycin-induced thrombocytopenia in a child with alveolar rhabdomyosarcoma. The phenomenon is consistent with an immune process leading to the formation of platelet-specific antibodies. This study shows that this can be induced even with the first dose of actinomycin, and its persistence is unpredictably prolonged and does not correlate linearly in an inverted fashion with the platelet count. It will be important to identify the subsets of patients who can develop this phenomenon by molecular techniques and to define the exact mechanism in vitro leading to formation of these antibodies. This would facilitate profiling the therapy, preventing the need for multiple platelet transfusions with their obvious hazards.
Original language | English (US) |
---|---|
Pages (from-to) | 777-779 |
Number of pages | 3 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 26 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2004 |
Keywords
- Alveolar rhabdomyosarcoma
- Autoimmune phenomenon
- Dactinomycin
- Identification of patients
- Thrombocytopenia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology