Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor

C. F. Pocock; G. F. Lucas; C. Giles; G. Vassiliou; K. Cwynarski; K. Rezvani; J. F. Apperley; J. M. Goldman

doi:10.1046/j.1365-2141.2001.02779.x

Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor

C. F. Pocock, G. F. Lucas, C. Giles, G. Vassiliou, K. Cwynarski, K. Rezvani, J. F. Apperley, J. M. Goldman

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, profound and unresponsive to granulocyte colony-stimulating factor (GCSF). The neutrophil count recovered after GCSF was discontinued. HNA-2a has been reported to be upregulated following GCSF administration. In the present case, it appears that the immune neutropenia may have been perpetuated by GCSF administration.

Original language	English (US)
Pages (from-to)	483-485
Number of pages	3
Journal	British Journal of Haematology
Volume	113
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02779.x
State	Published - 2001

Keywords

Allogeneic SCT
CML
GCSF
HNA-2a (NB1) antigen
Immune neutropenia

ASJC Scopus subject areas

Hematology

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Pocock, C. F., Lucas, G. F., Giles, C., Vassiliou, G., Cwynarski, K., Rezvani, K., Apperley, J. F., & Goldman, J. M. (2001). Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor. British Journal of Haematology, 113(2), 483-485. https://doi.org/10.1046/j.1365-2141.2001.02779.x

Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor. / Pocock, C. F.; Lucas, G. F.; Giles, C. et al.
In: British Journal of Haematology, Vol. 113, No. 2, 2001, p. 483-485.

Research output: Contribution to journal › Article › peer-review

Pocock, CF, Lucas, GF, Giles, C, Vassiliou, G, Cwynarski, K, Rezvani, K, Apperley, JF & Goldman, JM 2001, 'Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor', British Journal of Haematology, vol. 113, no. 2, pp. 483-485. https://doi.org/10.1046/j.1365-2141.2001.02779.x

Pocock CF, Lucas GF, Giles C, Vassiliou G, Cwynarski K, Rezvani K et al. Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor. British Journal of Haematology. 2001;113(2):483-485. doi: 10.1046/j.1365-2141.2001.02779.x

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title = "Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor",

abstract = "A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, profound and unresponsive to granulocyte colony-stimulating factor (GCSF). The neutrophil count recovered after GCSF was discontinued. HNA-2a has been reported to be upregulated following GCSF administration. In the present case, it appears that the immune neutropenia may have been perpetuated by GCSF administration.",

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AU - Lucas, G. F.

AU - Giles, C.

AU - Vassiliou, G.

AU - Cwynarski, K.

AU - Rezvani, K.

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AB - A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, profound and unresponsive to granulocyte colony-stimulating factor (GCSF). The neutrophil count recovered after GCSF was discontinued. HNA-2a has been reported to be upregulated following GCSF administration. In the present case, it appears that the immune neutropenia may have been perpetuated by GCSF administration.

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Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: Perpetuation by granulocyte colony-stimulating factor

Abstract

Keywords

ASJC Scopus subject areas

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