Immune regulation by novel costimulatory molecules

Chen Dong; Roza I. Nurieva; Durbaka V.R. Prasad

doi:10.1385/IR:28:1:39

Immune regulation by novel costimulatory molecules

Chen Dong, Roza I. Nurieva, Durbaka V.R. Prasad

Immunology

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

Original language	English (US)
Pages (from-to)	39-48
Number of pages	10
Journal	Immunologic Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1385/IR:28:1:39
State	Published - 2003

Keywords

Autoimmune diseases
B7-H3
Costimulation
Cytokines
Helper T-lymphocytes
Inducible costimulator
Th1/Th2

ASJC Scopus subject areas

Immunology

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10.1385/IR:28:1:39

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@article{0aa895d1d5f64866a0f5ba346f8e7ffa,

title = "Immune regulation by novel costimulatory molecules",

abstract = "CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.",

keywords = "Autoimmune diseases, B7-H3, Costimulation, Cytokines, Helper T-lymphocytes, Inducible costimulator, Th1/Th2",

author = "Chen Dong and Nurieva, {Roza I.} and Prasad, {Durbaka V.R.}",

note = "Funding Information: C. Dong is grateful to Dr. Richard Flavell at Yale University for mentorship. We thank our many collaborators for scientific contribution, Caroline Bishop and Heon Park for critical reading of the manuscript, and the entire Dong laboratory for discussion and help. This work was supported in part by a start-up fund from the Department of Immunology at University of Washington and by grants from the National Institutes of Health. C. Dong is a recipient of an Arthritis Investigator award from the Arthritis Foundation and a Basil O{\textquoteright}Connor Starter Scholar award from the March of Dimes Foundation for Birth Defects.",

year = "2003",

doi = "10.1385/IR:28:1:39",

language = "English (US)",

volume = "28",

pages = "39--48",

journal = "Immunologic Research",

issn = "0257-277X",

publisher = "Humana Press",

number = "1",

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T1 - Immune regulation by novel costimulatory molecules

AU - Dong, Chen

AU - Nurieva, Roza I.

AU - Prasad, Durbaka V.R.

N1 - Funding Information: C. Dong is grateful to Dr. Richard Flavell at Yale University for mentorship. We thank our many collaborators for scientific contribution, Caroline Bishop and Heon Park for critical reading of the manuscript, and the entire Dong laboratory for discussion and help. This work was supported in part by a start-up fund from the Department of Immunology at University of Washington and by grants from the National Institutes of Health. C. Dong is a recipient of an Arthritis Investigator award from the Arthritis Foundation and a Basil O’Connor Starter Scholar award from the March of Dimes Foundation for Birth Defects.

PY - 2003

Y1 - 2003

N2 - CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

AB - CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

KW - Autoimmune diseases

KW - B7-H3

KW - Costimulation

KW - Cytokines

KW - Helper T-lymphocytes

KW - Inducible costimulator

KW - Th1/Th2

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U2 - 10.1385/IR:28:1:39

DO - 10.1385/IR:28:1:39

M3 - Review article

C2 - 12947223

AN - SCOPUS:0042877332

SN - 0257-277X

VL - 28

SP - 39

EP - 48

JO - Immunologic Research

JF - Immunologic Research

IS - 1

ER -

Immune regulation by novel costimulatory molecules

Abstract

Keywords

ASJC Scopus subject areas

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