Abstract
The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors. On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.
Original language | English (US) |
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Article number | eabj7152 |
Journal | Science translational medicine |
Volume | 13 |
Issue number | 619 |
DOIs | |
State | Published - Nov 10 2021 |
ASJC Scopus subject areas
- General Medicine