Abstract
Rhesus monkeys were tested in vitro for their cellular immune response after infection with vaccinia virus, employing lymphocyte preparations from various lymphoid tissues. Although virus-infected target cells were lysed by lymphoid cells from immunized, but not from uninfected, rhesus monkeys, we could neither find evidence for MHC-restricted T cells nor for antibody-dependent cellular cytotoxicity. Kinetics of target cell lysis, the killing patterns of immune lymphocytes measured on syngeneic, allogeneic, and xenogeneic target cells, and the influence of protein A on cytotoxic activity in vitro suggest induction predominantly of natural killer cells in vivo which exhibit lytic activity on virus-infected target cells in vitro.
Original language | English (US) |
---|---|
Pages (from-to) | 237-250 |
Number of pages | 14 |
Journal | Pathobiology |
Volume | 52 |
Issue number | 4 |
DOIs | |
State | Published - 1984 |
Externally published | Yes |
Keywords
- Cellular immune response
- Rhesus monkey
- Vaccinia virus
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology