Immune suppression in the early stage of COVID-19 disease

Wenmin Tian; Nan Zhang; Ronghua Jin; Yingmei Feng; Siyuan Wang; Shuaixin Gao; Ruqin Gao; Guizhen Wu; Di Tian; Wenjie Tan; Yang Chen; George Fu Gao; Catherine C.L. Wong

doi:10.1038/s41467-020-19706-9

Immune suppression in the early stage of COVID-19 disease

Wenmin Tian, Nan Zhang, Ronghua Jin, Yingmei Feng, Siyuan Wang, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Di Tian, Wenjie Tan, Yang Chen, George Fu Gao, Catherine C.L. Wong

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.

Original language	English (US)
Article number	5859
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19706-9
State	Published - Dec 2020
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-020-19706-9

Cite this

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abstract = "The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.",

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AU - Tian, Wenmin

AU - Zhang, Nan

AU - Jin, Ronghua

AU - Feng, Yingmei

AU - Wang, Siyuan

AU - Gao, Shuaixin

AU - Gao, Ruqin

AU - Wu, Guizhen

AU - Tian, Di

AU - Tan, Wenjie

AU - Chen, Yang

AU - Gao, George Fu

AU - Wong, Catherine C.L.

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Immune suppression in the early stage of COVID-19 disease

Abstract

ASJC Scopus subject areas

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