Immunologic correlates of the abscopal effect in a patient with melanoma

Michael A. Postow; Margaret K. Callahan; Christopher A. Barker; Yoshiya Yamada; Jianda Yuan; Shigehisa Kitano; Zhenyu Mu; Teresa Rasalan; Matthew Adamow; Erika Ritter; Christine Sedrak; Achim A. Jungbluth; Ramon Chua; Arvin S. Yang; Ruth Ann Roman; Samuel Rosner; Brenna Benson; James P. Allison; Alexander M. Lesokhin; Sacha Gnjatic; Jedd D. Wolchok

doi:10.1056/NEJMoa1112824

Immunologic correlates of the abscopal effect in a patient with melanoma

Michael A. Postow, Margaret K. Callahan, Christopher A. Barker, Yoshiya Yamada, Jianda Yuan, Shigehisa Kitano, Zhenyu Mu, Teresa Rasalan, Matthew Adamow, Erika Ritter, Christine Sedrak, Achim A. Jungbluth, Ramon Chua, Arvin S. Yang, Ruth Ann Roman, Samuel Rosner, Brenna Benson, James P. Allison, Alexander M. Lesokhin, Sacha GnjaticJedd D. Wolchok

Research output: Contribution to journal › Article › peer-review

1681 Scopus citations

Abstract

The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)

Original language	English (US)
Pages (from-to)	925-931
Number of pages	7
Journal	New England Journal of Medicine
Volume	366
Issue number	10
DOIs	https://doi.org/10.1056/NEJMoa1112824
State	Published - Mar 8 2012
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1056/NEJMoa1112824

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Postow, M. A., Callahan, M. K., Barker, C. A., Yamada, Y., Yuan, J., Kitano, S., Mu, Z., Rasalan, T., Adamow, M., Ritter, E., Sedrak, C., Jungbluth, A. A., Chua, R., Yang, A. S., Roman, R. A., Rosner, S., Benson, B., Allison, J. P., Lesokhin, A. M., ... Wolchok, J. D. (2012). Immunologic correlates of the abscopal effect in a patient with melanoma. New England Journal of Medicine, 366(10), 925-931. https://doi.org/10.1056/NEJMoa1112824

Postow, MA, Callahan, MK, Barker, CA, Yamada, Y, Yuan, J, Kitano, S, Mu, Z, Rasalan, T, Adamow, M, Ritter, E, Sedrak, C, Jungbluth, AA, Chua, R, Yang, AS, Roman, RA, Rosner, S, Benson, B, Allison, JP, Lesokhin, AM, Gnjatic, S & Wolchok, JD 2012, 'Immunologic correlates of the abscopal effect in a patient with melanoma', New England Journal of Medicine, vol. 366, no. 10, pp. 925-931. https://doi.org/10.1056/NEJMoa1112824

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title = "Immunologic correlates of the abscopal effect in a patient with melanoma",

abstract = "The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)",

author = "Postow, {Michael A.} and Callahan, {Margaret K.} and Barker, {Christopher A.} and Yoshiya Yamada and Jianda Yuan and Shigehisa Kitano and Zhenyu Mu and Teresa Rasalan and Matthew Adamow and Erika Ritter and Christine Sedrak and Jungbluth, {Achim A.} and Ramon Chua and Yang, {Arvin S.} and Roman, {Ruth Ann} and Samuel Rosner and Brenna Benson and Allison, {James P.} and Lesokhin, {Alexander M.} and Sacha Gnjatic and Wolchok, {Jedd D.}",

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AU - Yuan, Jianda

AU - Kitano, Shigehisa

AU - Mu, Zhenyu

AU - Rasalan, Teresa

AU - Adamow, Matthew

AU - Ritter, Erika

AU - Sedrak, Christine

AU - Jungbluth, Achim A.

AU - Chua, Ramon

AU - Yang, Arvin S.

AU - Roman, Ruth Ann

AU - Rosner, Samuel

AU - Benson, Brenna

AU - Allison, James P.

AU - Lesokhin, Alexander M.

AU - Gnjatic, Sacha

AU - Wolchok, Jedd D.

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AB - The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)

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Immunologic correlates of the abscopal effect in a patient with melanoma

Abstract

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