TY - JOUR
T1 - Immunologic evaluation in the nutritional assessment of children with cancer
AU - Ramirez, I.
AU - van Eys, J.
AU - Carr, D.
AU - Coody, D.
AU - Carter-George, P.
AU - Washington, J.
AU - Richie, E.
AU - Taylor, G.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Eighty-one newly diagnosed untreated pediatric cancer patients (48 hematopoietic malignancies, 17 solid tumors, 16 benign diseases) were evaluated with immunologic and nutritional parameters. The mean absolute lymphocyte count was adequate in the three groups. Reduced T-lymphocytes were seen in the solid tumors. Mitogenic response of hematopoietic and solid tumor patients' lymphocytes was low. Correlation of immunologic, dietary, and nutritional factors showed that for patients with solid tumors there was a positive significant correlation between weight/height percent and lymphocyte reactivity to phytohemagglutinin, concanavalin A, and pokeweed mitogen (p < .05). Iron intake showed a significant positive correlation with in vitro mitogen reactivity for the solid tumor group (p < .05) and benign diseases (p < 0.01). Immune derangements found among patients with hematopoietic malignancies can be due to replacement of normal bone marrow with malignant cells. In solid tumor patients mitogen reactivity appears to be a reflection of nutritional state, and dietary iron is a possible factor.
AB - Eighty-one newly diagnosed untreated pediatric cancer patients (48 hematopoietic malignancies, 17 solid tumors, 16 benign diseases) were evaluated with immunologic and nutritional parameters. The mean absolute lymphocyte count was adequate in the three groups. Reduced T-lymphocytes were seen in the solid tumors. Mitogenic response of hematopoietic and solid tumor patients' lymphocytes was low. Correlation of immunologic, dietary, and nutritional factors showed that for patients with solid tumors there was a positive significant correlation between weight/height percent and lymphocyte reactivity to phytohemagglutinin, concanavalin A, and pokeweed mitogen (p < .05). Iron intake showed a significant positive correlation with in vitro mitogen reactivity for the solid tumor group (p < .05) and benign diseases (p < 0.01). Immune derangements found among patients with hematopoietic malignancies can be due to replacement of normal bone marrow with malignant cells. In solid tumor patients mitogen reactivity appears to be a reflection of nutritional state, and dietary iron is a possible factor.
UR - http://www.scopus.com/inward/record.url?scp=0021802884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021802884&partnerID=8YFLogxK
U2 - 10.1093/ajcn/41.6.1314
DO - 10.1093/ajcn/41.6.1314
M3 - Article
C2 - 3873869
AN - SCOPUS:0021802884
SN - 0002-9165
VL - 41
SP - 1314
EP - 1321
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 6
ER -