TY - JOUR
T1 - Immunotherapy and systemic treatment of cutaneous squamous cell carcinoma
AU - Aboul-Fettouh, Nader
AU - Morse, Daniel
AU - Patel, Jigar
AU - Migden, Michael R.
N1 - Publisher Copyright:
© 2021 Volcanica. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targetedapproaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease.
AB - Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targetedapproaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease.
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U2 - 10.5826/dpc.11S2a169S
DO - 10.5826/dpc.11S2a169S
M3 - Article
C2 - 34877077
AN - SCOPUS:85120749102
SN - 2160-9381
VL - 11
JO - Dermatology Practical and Conceptual
JF - Dermatology Practical and Conceptual
M1 - e2021169S
ER -