@article{a32f2014bdf147dcb8da405858d52385,
title = "Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q",
abstract = "This cooperative study assessed prognostic factors for overall survival (OS) and risk of transformation to acute myeloid leukemia (AML) in 541 patients with de novo myelodysplastic syndrome (MDS) and deletion 5q. Additional chromosomal abnormalities were strongly related to different patients characteristics. In multivariate analysis, the most important predictors of both OS and AML transformation risk were number of chromosomal abnormalities (P0.001 for both outcomes), platelet count (P0.001 and P0.001, respectively) and proportion of bone marrow blasts (P0.001 and P0.016, respectively). The number of chromosomal abnormalities defined three risk categories for AML transformation (del(5q), del(5q)1 and del(5q)2 abnormalities) and two for OS (one group: del(5q) and del(5q)1; and del(5q)2 abnormalities, as the other one); with a median survival time of 58.0 and 6.8 months, respectively. Platelet count (P0.001) and age (P0.034) predicted OS in patients with 5qsyndrome. This study demonstrates the importance of additional chromosomal abnormalities in MDS patients with deletion 5q, challenges the current 5qsyndrome definition and constitutes a useful reference series to properly analyze the results of clinical trials in these patients.",
keywords = "5qsyndrome', cytogenetics, deletion 5q, myelodysplastic syndromes",
author = "M. Mallo and J. Cervera and J. Schanz and E. Such and G. Garc{\'i}a-Manero and E. Lũo and C. Steidl and B. Espinet and T. Vallesp{\'i} and U. Germing and S. Blum and K. Ohyashiki and J. Grau and M. Pfeilst{\"o}cker and Hern{\'a}ndez, {J. M.} and T. Noesslinger and A. Giagounidis and C. Aul and Calasanz, {M. J.} and Mart{\'i}n, {M. L.} and P. Valent and R. Collado and C. Haferlach and C. Fonatsch and M. L{\"u}bbert and R. Stauder and B. Hildebrandt and O. Krieger and C. Pedro and L. Arenillas and M. Sanz and A. Valencia and L. Florensa and Sanz, {G. F.} and D. Haase and F. Sol{\'e}",
note = "Funding Information: This work was supported (in part) by grants from the Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain (FI07/ 00107, CA08/00141 and PI07/1009) to MM, MAS and LF, respectively; Red Tem{\'a}tica de Investigaci{\'o}n Cooperativa en C{\'a}ncer (RTICC and FEDER) (RD06/0020/0031 and RD07/0020/ 2004) to MAS and FS; the European Leukemia Net; and the National Institutes of Health (NIH) grants (5PO11CA108631) to GGM. We are grateful to the Myelodysplastic Syndromes Foundation for supporting this international project. We thank Luis Benlloch, Francesc Garcia-Pallarols and Lara Nonell, for their excellent technical assistance. We thank Encarna Bureo, Marina Recio, Virginie Eclache, Daniel Armenta-Gil, Jos{\'e} {\'A}ngel Mart{\'i}nez-Climent, Isana Benet, Esperanza Vizcarra, Eva Arranz, Juan C. Cigudosa and groups belonging to the Spanish Registry of MDS, as well as the technicians involved in all cytogenetics laboratories.",
year = "2011",
month = jan,
doi = "10.1038/leu.2010.231",
language = "English (US)",
volume = "25",
pages = "110--120",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "1",
}