TY - JOUR
T1 - Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function
AU - ORZABAL, MARCUS R.
AU - NAIK, VISHAL D.
AU - LEE, JEHOON
AU - HILLHOUSE, ANDREW E.
AU - BRASHEAR, WESLEY A.
AU - THREADGILL, DAVID W.
AU - RAMADOSS, JAYANTH
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/8
Y1 - 2022/8
N2 - Electronic cigarette (e-cig) use has increased over the past decade, and exposure to e-cig aerosols during pregnancy raises concern for maternal and fetal health. The developing fetal lung is known to be sensitive to prenatal tobacco product exposure. Utilizing a 3-pronged approach, we examined the effects of prenatal e-cig aerosols with, and without nicotine on respiratory development in a murine model. RNAseq analysis of fetal lungs revealed extensive dysregulation in gene expression. Morphologic assessment of distal airspaces in neonatal lungs display an emphysematic phenotype. Respiratory mechanics of neonates display signs of increased respiratory workload, with increased resistance and decreased compliance. These data are novel and provide evidence that prenatal e-cig exposure may result in altered lung function or development of disease.
AB - Electronic cigarette (e-cig) use has increased over the past decade, and exposure to e-cig aerosols during pregnancy raises concern for maternal and fetal health. The developing fetal lung is known to be sensitive to prenatal tobacco product exposure. Utilizing a 3-pronged approach, we examined the effects of prenatal e-cig aerosols with, and without nicotine on respiratory development in a murine model. RNAseq analysis of fetal lungs revealed extensive dysregulation in gene expression. Morphologic assessment of distal airspaces in neonatal lungs display an emphysematic phenotype. Respiratory mechanics of neonates display signs of increased respiratory workload, with increased resistance and decreased compliance. These data are novel and provide evidence that prenatal e-cig exposure may result in altered lung function or development of disease.
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U2 - 10.1016/j.trsl.2022.03.009
DO - 10.1016/j.trsl.2022.03.009
M3 - Article
C2 - 35351623
AN - SCOPUS:85131640544
SN - 1931-5244
VL - 246
SP - 102
EP - 114
JO - Translational Research
JF - Translational Research
ER -