Impact of high neutrophil-to-lymphocyte ratio on survival in hospitalized cancer patients with COVID-19

Fernando A. Díaz-Couselo; Santiago Flagel; Carla Nicolini; Sebastián Halac; Natalia Manzano; Marina Aguirre; Juan Rébora; Sandra Valle; Laura Noro; Chirayu Mohindroo; Florencia McAllister; Marcelo Zylberman

doi:10.1002/cam4.5426

Impact of high neutrophil-to-lymphocyte ratio on survival in hospitalized cancer patients with COVID-19

Fernando A. Díaz-Couselo, Santiago Flagel, Carla Nicolini, Sebastián Halac, Natalia Manzano, Marina Aguirre, Juan Rébora, Sandra Valle, Laura Noro, Chirayu Mohindroo, Florencia McAllister, Marcelo Zylberman

Clinical Cancer Prevention

Research output: Contribution to journal › Article › peer-review

Abstract

Neutrophil-to-lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID-19 patients. Our study aimed to evaluate the association between NLR at COVID-19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID-19, an NLR > 8.3 is associated with an increased risk of death.

Original language	English (US)
Pages (from-to)	7164-7169
Number of pages	6
Journal	Cancer medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/cam4.5426
State	Published - Mar 2023

Keywords

biomarkers
cancer
COVID-19
inflammatory markers
neutrophil lymphocyte ratio
neutrophils
NLR

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1002/cam4.5426

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title = "Impact of high neutrophil-to-lymphocyte ratio on survival in hospitalized cancer patients with COVID-19",

abstract = "Neutrophil-to-lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID-19 patients. Our study aimed to evaluate the association between NLR at COVID-19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID-19, an NLR > 8.3 is associated with an increased risk of death.",

keywords = "biomarkers, cancer, COVID-19, inflammatory markers, neutrophil lymphocyte ratio, neutrophils, NLR",

author = "D{\'i}az-Couselo, {Fernando A.} and Santiago Flagel and Carla Nicolini and Sebasti{\'a}n Halac and Natalia Manzano and Marina Aguirre and Juan R{\'e}bora and Sandra Valle and Laura Noro and Chirayu Mohindroo and Florencia McAllister and Marcelo Zylberman",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",

year = "2023",

month = mar,

doi = "10.1002/cam4.5426",

language = "English (US)",

volume = "12",

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T1 - Impact of high neutrophil-to-lymphocyte ratio on survival in hospitalized cancer patients with COVID-19

AU - Díaz-Couselo, Fernando A.

AU - Flagel, Santiago

AU - Nicolini, Carla

AU - Halac, Sebastián

AU - Manzano, Natalia

AU - Aguirre, Marina

AU - Rébora, Juan

AU - Valle, Sandra

AU - Noro, Laura

AU - Mohindroo, Chirayu

AU - McAllister, Florencia

AU - Zylberman, Marcelo

PY - 2023/3

Y1 - 2023/3

N2 - Neutrophil-to-lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID-19 patients. Our study aimed to evaluate the association between NLR at COVID-19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID-19, an NLR > 8.3 is associated with an increased risk of death.

AB - Neutrophil-to-lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID-19 patients. Our study aimed to evaluate the association between NLR at COVID-19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID-19, an NLR > 8.3 is associated with an increased risk of death.

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KW - COVID-19

KW - inflammatory markers

KW - neutrophil lymphocyte ratio

KW - neutrophils

KW - NLR

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Impact of high neutrophil-to-lymphocyte ratio on survival in hospitalized cancer patients with COVID-19

Abstract

Keywords

ASJC Scopus subject areas

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