Impact of molecular profiling on clinical trial design for glioblastoma

Arnab Chakravarti; Erin Tyndall; Kamalakannan Palanichamy; Minesh Mehta; Kenneth Aldape; Jay Loeffler

doi:10.1007/BF02951429

Impact of molecular profiling on clinical trial design for glioblastoma

Arnab Chakravarti, Erin Tyndall, Kamalakannan Palanichamy, Minesh Mehta, Kenneth Aldape, Jay Loeffler

Pathology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

This review highlights the ways in which molecular and genetic profiling of malignant gliomas has led to intelligent clinical trial: design. The review also highlights known resistance mechanisms to conventional therapies in malignant gliomas and potential strategies to overcome these mechanisms with the use of targeted therapy.

Original language	English (US)
Pages (from-to)	71-79
Number of pages	9
Journal	Current oncology reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1007/BF02951429
State	Published - Jan 2007

ASJC Scopus subject areas

Oncology

MD Anderson CCSG core facilities

Advanced Technology Genomics Core

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10.1007/BF02951429

Cite this

@article{a7a8fee45a934b1e96cdd1dc389f137b,

title = "Impact of molecular profiling on clinical trial design for glioblastoma",

abstract = "This review highlights the ways in which molecular and genetic profiling of malignant gliomas has led to intelligent clinical trial: design. The review also highlights known resistance mechanisms to conventional therapies in malignant gliomas and potential strategies to overcome these mechanisms with the use of targeted therapy.",

author = "Arnab Chakravarti and Erin Tyndall and Kamalakannan Palanichamy and Minesh Mehta and Kenneth Aldape and Jay Loeffler",

year = "2007",

month = jan,

doi = "10.1007/BF02951429",

language = "English (US)",

volume = "9",

pages = "71--79",

journal = "Current oncology reports",

issn = "1523-3790",

publisher = "Current Science, Inc.",

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T1 - Impact of molecular profiling on clinical trial design for glioblastoma

AU - Chakravarti, Arnab

AU - Tyndall, Erin

AU - Palanichamy, Kamalakannan

AU - Mehta, Minesh

AU - Aldape, Kenneth

AU - Loeffler, Jay

PY - 2007/1

Y1 - 2007/1

N2 - This review highlights the ways in which molecular and genetic profiling of malignant gliomas has led to intelligent clinical trial: design. The review also highlights known resistance mechanisms to conventional therapies in malignant gliomas and potential strategies to overcome these mechanisms with the use of targeted therapy.

AB - This review highlights the ways in which molecular and genetic profiling of malignant gliomas has led to intelligent clinical trial: design. The review also highlights known resistance mechanisms to conventional therapies in malignant gliomas and potential strategies to overcome these mechanisms with the use of targeted therapy.

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U2 - 10.1007/BF02951429

DO - 10.1007/BF02951429

M3 - Review article

C2 - 17164051

AN - SCOPUS:33846130612

SN - 1523-3790

VL - 9

SP - 71

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JO - Current oncology reports

JF - Current oncology reports

IS - 1

ER -

Impact of molecular profiling on clinical trial design for glioblastoma

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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