TY - JOUR
T1 - Impact of race, ethnicity, and socioeconomic status over time on the long-term survival of adolescent and young adult hodgkin lymphoma survivors
AU - Berkman, Amy M.
AU - Andersen, Clark R.
AU - Puthenpura, Vidya
AU - Livingston, J. Andrew
AU - Ahmed, Sairah
AU - Cuglievan, Branko
AU - Hildebrandt, Michelle A.T.
AU - Roth, Michael E.
N1 - Funding Information:
This work was supported by the National Cancer Institute at the National Institutes of Health (grant number P30 CA016672, M.E. Roth, J.A. Livingston, C.R. Anderson, and M.A.T. Hildebrandt) and (R38-HL143612, A.M. Berkman) and research support from the Archer Foundation and LyondellBasell (M.E. Roth, J.A. Livingston). The funders had no role in the design of the study, conduct of the study, analysis, interpretation of data, or decision to submit the manuscript for publication.
Publisher Copyright:
© 2021 American Association for Cancer Research.
PY - 2021/9
Y1 - 2021/9
N2 - Background: Although there are growing numbers of adolescent and young adult (AYA) Hodgkin lymphoma (HL) survivors, long-term overall survival (OS) patterns and disparities in this population are underreported. The aim of the current study was to assess the impact of race/ ethnicity, socioeconomic status (SES), rurality, diagnosis age, sex, and HL stage over time on long-term survival in AYA HL survivors. Methods: The authors used the Surveillance, Epidemiology, and End Results (SEER) registry to identify survivors of HL diagnosed as AYAs (ages 15-39 years) between the years 1980 and 2009 and who were alive 5 years after diagnosis. An accelerated failure time model was used to estimate survival over time and compare survival between groups. Results: There were 15, 899 5-year survivors of AYA HL identified, with amedian follow-up of 14.4 years and range up to 33.9 years from diagnosis. Non-Hispanic black survivors had inferior survival compared with non-Hispanic white survivors [survival time ratio (STR): 0.71, P = 0.002]. Male survivors, older age at diagnosis, those diagnosed at higher stages, and those living in areas of higher SES deprivation had unfavorable long-term survival. There was no evidence of racial or sex-based survival disparities changing over time. Conclusions: Racial, SES, and sex-based disparities persist well into survivorship among AYA HL survivors. Impact: Disparities in long-term survival among AYA HL survivors show no evidence of improving over time. Studies investigating specific factors associated with survival disparities are needed to identify opportunities for intervention.
AB - Background: Although there are growing numbers of adolescent and young adult (AYA) Hodgkin lymphoma (HL) survivors, long-term overall survival (OS) patterns and disparities in this population are underreported. The aim of the current study was to assess the impact of race/ ethnicity, socioeconomic status (SES), rurality, diagnosis age, sex, and HL stage over time on long-term survival in AYA HL survivors. Methods: The authors used the Surveillance, Epidemiology, and End Results (SEER) registry to identify survivors of HL diagnosed as AYAs (ages 15-39 years) between the years 1980 and 2009 and who were alive 5 years after diagnosis. An accelerated failure time model was used to estimate survival over time and compare survival between groups. Results: There were 15, 899 5-year survivors of AYA HL identified, with amedian follow-up of 14.4 years and range up to 33.9 years from diagnosis. Non-Hispanic black survivors had inferior survival compared with non-Hispanic white survivors [survival time ratio (STR): 0.71, P = 0.002]. Male survivors, older age at diagnosis, those diagnosed at higher stages, and those living in areas of higher SES deprivation had unfavorable long-term survival. There was no evidence of racial or sex-based survival disparities changing over time. Conclusions: Racial, SES, and sex-based disparities persist well into survivorship among AYA HL survivors. Impact: Disparities in long-term survival among AYA HL survivors show no evidence of improving over time. Studies investigating specific factors associated with survival disparities are needed to identify opportunities for intervention.
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U2 - 10.1158/1055-9965.EPI-21-0103
DO - 10.1158/1055-9965.EPI-21-0103
M3 - Article
C2 - 34244160
AN - SCOPUS:85114149732
SN - 1055-9965
VL - 30
SP - 1717
EP - 1725
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -