Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans

Jose P. Zevallos; Vlad C. Sandulache; John Hamblin; Heath D. Skinner; Jennifer Kramer; Christine M. Hartman; Kelsey L. Horter; Syeling Lai; Xiaodong Zhou; Elizabeth Y. Chiao

doi:10.1002/hed.23836

Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans

Jose P. Zevallos, Vlad C. Sandulache, John Hamblin, Heath D. Skinner, Jennifer Kramer, Christine M. Hartman, Kelsey L. Horter, Syeling Lai, Xiaodong Zhou, Elizabeth Y. Chiao

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. Methods Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. Results Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p =.372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p =.768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. Conclusion Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor.

Original language	English (US)
Pages (from-to)	44-50
Number of pages	7
Journal	Head and Neck
Volume	38
Issue number	1
DOIs	https://doi.org/10.1002/hed.23836
State	Published - Jan 1 2016

Keywords

oropharyngeal cancer
racial disparities
veterans

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23836

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title = "Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans",

abstract = "Background Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. Methods Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. Results Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p =.372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p =.768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. Conclusion Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor.",

keywords = "oropharyngeal cancer, racial disparities, veterans",

author = "Zevallos, {Jose P.} and Sandulache, {Vlad C.} and John Hamblin and Skinner, {Heath D.} and Jennifer Kramer and Hartman, {Christine M.} and Horter, {Kelsey L.} and Syeling Lai and Xiaodong Zhou and Chiao, {Elizabeth Y.}",

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T1 - Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans

AU - Zevallos, Jose P.

AU - Sandulache, Vlad C.

AU - Hamblin, John

AU - Skinner, Heath D.

AU - Kramer, Jennifer

AU - Hartman, Christine M.

AU - Horter, Kelsey L.

AU - Lai, Syeling

AU - Zhou, Xiaodong

AU - Chiao, Elizabeth Y.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. Methods Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. Results Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p =.372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p =.768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. Conclusion Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor.

AB - Background Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. Methods Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. Results Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p =.372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p =.768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. Conclusion Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor.

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Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans

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