TY - JOUR
T1 - Impact on patient outcome following transfusion of bacterially contaminated platelets
T2 - The M.D. Anderson Cancer Center experience
AU - Martínez, Fernando
AU - Tarrand, Jeffrey
AU - Lichtiger, Benjamin
PY - 2010/8
Y1 - 2010/8
N2 - This study examined the clinical outcome of every patient who received a bacterially contaminated unit of platelets at The University of Texas M.D. Anderson Cancer Center, Houston, during 2007. Samples of platelets were aerobically cultured and read for 1 day at 35°C. Positive bottles were subcultured in the appropriate media. The effect of independent variables in the clinical outcome of patients infused with bacterially contaminated platelet units was analyzed. A total of 23,199 platelet units were transfused, 71 of which were bacterially contaminated units; 8 were apheresis platelets and 63 were whole blood platelets. Of the 71 units, 70 were contaminated with gram-positive bacteria and 1 with gram-negative bacteria. Only 1 patient developed fever, and coagulase-negative staphylococci were isolated from the transfused unit. Transfusion of fresh units and antibiotic therapy possibly explain the lack of clinical consequences in our patients.
AB - This study examined the clinical outcome of every patient who received a bacterially contaminated unit of platelets at The University of Texas M.D. Anderson Cancer Center, Houston, during 2007. Samples of platelets were aerobically cultured and read for 1 day at 35°C. Positive bottles were subcultured in the appropriate media. The effect of independent variables in the clinical outcome of patients infused with bacterially contaminated platelet units was analyzed. A total of 23,199 platelet units were transfused, 71 of which were bacterially contaminated units; 8 were apheresis platelets and 63 were whole blood platelets. Of the 71 units, 70 were contaminated with gram-positive bacteria and 1 with gram-negative bacteria. Only 1 patient developed fever, and coagulase-negative staphylococci were isolated from the transfused unit. Transfusion of fresh units and antibiotic therapy possibly explain the lack of clinical consequences in our patients.
KW - Blood safety
KW - Contaminated platelets
KW - Transfusion microbiology
UR - http://www.scopus.com/inward/record.url?scp=77955601238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955601238&partnerID=8YFLogxK
U2 - 10.1309/AJCPS9YV7YTOMRRH
DO - 10.1309/AJCPS9YV7YTOMRRH
M3 - Article
C2 - 20660322
AN - SCOPUS:77955601238
SN - 0002-9173
VL - 134
SP - 207
EP - 212
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 2
ER -