Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction

Mohamed A. Naser, Diego R.T. Sampaio, Nina M. Munoz, Cayla A. Wood, Trevor M. Mitcham, Wolfgang Stefan, Konstantin V Sokolov, Theo Z. Pavan, Rony Avritscher, Richard R Bouchard

Research output: Contribution to journalArticle

Abstract

As photoacoustic (PA) imaging makes its way into the clinic, the accuracy of PA-based metrics becomes increasingly important. To address this need, a method combining finite-element-based local fluence correction (LFC) with signal-to-noise-ratio (SNR) regularization was developed and validated to accurately estimate oxygen saturation (SO 2 ) in tissue. With data from a Vevo LAZR system, performance of our LFC approach was assessed in ex vivo blood targets (37.6%-99.6% SO 2 ) and in vivo rat arteries. Estimation error of absolute SO 2 and change in SO 2 reduced from 10.1% and 6.4%, respectively, without LFC to 2.8% and 2.0%, respectively, with LFC, while the accuracy of the LFC method was correlated with the number of wavelengths acquired. This paper demonstrates the need for an SNR-regularized LFC to accurately quantify SO 2 with PA imaging.

Original languageEnglish (US)
Article number8458163
Pages (from-to)561-571
Number of pages11
JournalIEEE Transactions on Medical Imaging
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Photoacoustic effect
Signal-To-Noise Ratio
Signal to noise ratio
Oxygen
Imaging techniques
Arteries
Error analysis
Rats
Blood
Tissue
Finite element method
Wavelength

Keywords

  • Photoacoustic imaging
  • finite element modeling
  • image reconstruction methods
  • liver
  • ultrasound

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction. / Naser, Mohamed A.; Sampaio, Diego R.T.; Munoz, Nina M.; Wood, Cayla A.; Mitcham, Trevor M.; Stefan, Wolfgang; Sokolov, Konstantin V; Pavan, Theo Z.; Avritscher, Rony; Bouchard, Richard R.

In: IEEE Transactions on Medical Imaging, Vol. 38, No. 2, 8458163, 01.02.2019, p. 561-571.

Research output: Contribution to journalArticle

Naser, Mohamed A. ; Sampaio, Diego R.T. ; Munoz, Nina M. ; Wood, Cayla A. ; Mitcham, Trevor M. ; Stefan, Wolfgang ; Sokolov, Konstantin V ; Pavan, Theo Z. ; Avritscher, Rony ; Bouchard, Richard R. / Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction. In: IEEE Transactions on Medical Imaging. 2019 ; Vol. 38, No. 2. pp. 561-571.
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