Abstract
Drinking an herbal tea to lose weight is a well-liked concept. This study was designed to examine the possible improvement of obesity phenotype by a new tea represented by its purified components, gallic acid, ellagic acid, and rubusoside (GER). Male obese-prone SD rats were given low-fat diet, high-fat diet, or high-fat diet plus GER at the dose of 0.22 g/kg of body weight for 9 weeks. GER significantly reduced body weight gain by 22% compared to the high-fat diet control group with 48% less abdominal fat gain. Food intake was not affected. Blood glucose was lowered in the GER-treated group, whereas serum triglycerides and cholesterol were significantly reduced by 50%. This improved obesity phenotype may be associated with the attenuated expression of vascular endothelial growth factor in preadipocyte 3T3-L1 cells. Although other underlying, possibly multiple, mechanisms behind the improved phenotype are largely unknown, the observed improvement of multiple obesity-related parameters by the new tea warrants further investigations.
Original language | English (US) |
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Pages (from-to) | 98-104 |
Number of pages | 7 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 59 |
Issue number | 1 |
DOIs | |
State | Published - Jan 12 2011 |
Keywords
- Chinese sweet leaf tea
- Rubus suavissimus
- ellagic acid
- gallic acid
- obesity
- rubusoside
ASJC Scopus subject areas
- General Chemistry
- General Agricultural and Biological Sciences