In this issue: Targeting human papilloma virus-associated disease, from cervical to head and neck carcinoma⋯ and more

This issue of the International Reviews of Immunology hosts a diverse range of topics, ranging from cancer immunotherapy, to severe combined immunodeficiency syndromes in man and alternative treatments for autoimmunity. The emphasis of the issue is on cervical and head and neck carcinoma, significantly related to Human Papilloma Viruses. While the development of anti-HPV prophylactic vaccines represents one of the most remarkable triumphs of modern medicine, there is much more to be done in terms of advancing safe and effective treatments for cervical and head-and-neck cancers. We also host a review on congenital severe combined immunodeficiencies, a field that allowed unprecedented insight into the connection between the immune system, microbes, autoimmunity and cancer. Last but not least, we host a review dedicated to critically analyzing alternative treatments for Inflammatory Bowel Disease, as adjuncts to conventional therapies, based on solid scientific evidence and complementary mechanism of action.