Abstract
Various potential in vitro correlates of malignancy were studied in four chemically transformed C3H/10T 1 /2 Clone 8 mouse cell lines and were compared with control cells. The degree of tumorigenicity was best predicted by the relative plating efficiencies of the morphologically transformed cells in soft agar. All transformed cells also showed an increase in extracellular fibrinolytic activity which may be an additional marker for transformation. Intracellular fibrinolytic activity and loss of 125 l-labeled cell surface protein (M.W. 250,000) were not correlated with morphological transformation or tumorigenicity in these cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2863-2867 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 36 |
| Issue number | 8 |
| State | Published - Aug 1976 |
ASJC Scopus subject areas
- Oncology
- Cancer Research