In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network

Shawn R. Lockhart; Alicia J. Zimbeck; John W. Baddley; Kieren A. Marr; David R. Andes; Thomas J. Walsh; Carol A. Kauffman; Dimitrios P. Kontoyiannis; James I. Ito; Peter G. Pappas; Tom Chiller

doi:10.1128/AAC.00428-11

In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network

Shawn R. Lockhart, Alicia J. Zimbeck, John W. Baddley, Kieren A. Marr, David R. Andes, Thomas J. Walsh, Carol A. Kauffman, Dimitrios P. Kontoyiannis, James I. Ito, Peter G. Pappas, Tom Chiller

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

We determined the echinocandin minimum effective concentration (MEC) values for caspofungin, micafungin, and anidulafungin against 288 Aspergillus isolates prospectively collected from transplant patients with proven or probable invasive aspergillosis between 2001 and 2006 as part of the Transplant- Associated Infection Surveillance Network (TRANSNET). We demonstrated that the vast majority of Aspergillus isolates had MEC values at or below the epidemiological cutoff values for caspofungin, micafungin, and anidulafungin, including those from patients who had received caspofungin.

Original language	English (US)
Pages (from-to)	3944-3946
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00428-11
State	Published - Aug 2011

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Lockhart, S. R., Zimbeck, A. J., Baddley, J. W., Marr, K. A., Andes, D. R., Walsh, T. J., Kauffman, C. A., Kontoyiannis, D. P., Ito, J. I., Pappas, P. G., & Chiller, T. (2011). In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network. Antimicrobial agents and chemotherapy, 55(8), 3944-3946. https://doi.org/10.1128/AAC.00428-11

Lockhart, SR, Zimbeck, AJ, Baddley, JW, Marr, KA, Andes, DR, Walsh, TJ, Kauffman, CA, Kontoyiannis, DP, Ito, JI, Pappas, PG & Chiller, T 2011, 'In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network', Antimicrobial agents and chemotherapy, vol. 55, no. 8, pp. 3944-3946. https://doi.org/10.1128/AAC.00428-11

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title = "In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network",

abstract = "We determined the echinocandin minimum effective concentration (MEC) values for caspofungin, micafungin, and anidulafungin against 288 Aspergillus isolates prospectively collected from transplant patients with proven or probable invasive aspergillosis between 2001 and 2006 as part of the Transplant- Associated Infection Surveillance Network (TRANSNET). We demonstrated that the vast majority of Aspergillus isolates had MEC values at or below the epidemiological cutoff values for caspofungin, micafungin, and anidulafungin, including those from patients who had received caspofungin.",

author = "Lockhart, {Shawn R.} and Zimbeck, {Alicia J.} and Baddley, {John W.} and Marr, {Kieren A.} and Andes, {David R.} and Walsh, {Thomas J.} and Kauffman, {Carol A.} and Kontoyiannis, {Dimitrios P.} and Ito, {James I.} and Pappas, {Peter G.} and Tom Chiller",

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doi = "10.1128/AAC.00428-11",

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AU - Marr, Kieren A.

AU - Andes, David R.

AU - Walsh, Thomas J.

AU - Kauffman, Carol A.

AU - Kontoyiannis, Dimitrios P.

AU - Ito, James I.

AU - Pappas, Peter G.

AU - Chiller, Tom

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AB - We determined the echinocandin minimum effective concentration (MEC) values for caspofungin, micafungin, and anidulafungin against 288 Aspergillus isolates prospectively collected from transplant patients with proven or probable invasive aspergillosis between 2001 and 2006 as part of the Transplant- Associated Infection Surveillance Network (TRANSNET). We demonstrated that the vast majority of Aspergillus isolates had MEC values at or below the epidemiological cutoff values for caspofungin, micafungin, and anidulafungin, including those from patients who had received caspofungin.

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In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network

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