In vivo cell death mediated by synthetic ion channels

Bryan A. Smith; Megan M. Daschbach; Seth T. Gammon; Shuzhang Xiao; Sarah E. Chapman; Caroline Hudson; Mark Suckow; David Piwnica-Worms; George W. Gokel; W. Matthew Leevy

doi:10.1039/c1cc12933c

In vivo cell death mediated by synthetic ion channels

Bryan A. Smith, Megan M. Daschbach, Seth T. Gammon, Shuzhang Xiao, Sarah E. Chapman, Caroline Hudson, Mark Suckow, David Piwnica-Worms, George W. Gokel, W. Matthew Leevy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Original language	English (US)
Pages (from-to)	7977-7979
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	28
DOIs	https://doi.org/10.1039/c1cc12933c
State	Published - Jul 28 2011
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc12933c

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title = "In vivo cell death mediated by synthetic ion channels",

abstract = "Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.",

author = "Smith, {Bryan A.} and Daschbach, {Megan M.} and Gammon, {Seth T.} and Shuzhang Xiao and Chapman, {Sarah E.} and Caroline Hudson and Mark Suckow and David Piwnica-Worms and Gokel, {George W.} and Leevy, {W. Matthew}",

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AU - Smith, Bryan A.

AU - Daschbach, Megan M.

AU - Gammon, Seth T.

AU - Xiao, Shuzhang

AU - Chapman, Sarah E.

AU - Hudson, Caroline

AU - Suckow, Mark

AU - Piwnica-Worms, David

AU - Gokel, George W.

AU - Leevy, W. Matthew

PY - 2011/7/28

Y1 - 2011/7/28

N2 - Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

AB - Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

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In vivo cell death mediated by synthetic ion channels

Abstract

ASJC Scopus subject areas

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