In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound

Mallory R. Scola; Leslie M. Baggesen; Russel H. Behler; Timothy C. Nichols; Hongtu Zhu; Melissa C. Caughey; Elizabeth P. Merricks; Robin A. Raymer; Paris Margaritis; Katherine A. High; Caterina M. Gallippi

doi:10.1109/ULTSYM.2011.0160

In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound

Mallory R. Scola, Leslie M. Baggesen, Russel H. Behler, Timothy C. Nichols, Hongtu Zhu, Melissa C. Caughey, Elizabeth P. Merricks, Robin A. Raymer, Paris Margaritis, Katherine A. High, Caterina M. Gallippi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

There is currently no validated method for assessing hemostasis in vivo. Such a method would facilitate the development of therapeutic clotting factor replacement products for patients with bleeding disorders as well as improve patient care and reduce complications following invasive procedures. We have investigated the use of Acoustic Radiation Force Impulse (ARFI) imaging as a method for assessing bleeding rate in vivo in dog models of inherited bleeding disorders and in human volunteers following arteriotomy for diagnostic percutaneous cardiac catheterization. Our data showed significantly higher bleeding rates in the VWD dogs consistent with the inherited bleeding phenotype. We also saw slower arteriotomy bleeding rates after 5 minutes when a hemostatic dressing is used to augment manual compression. These results suggest that ARFI imaging is relevant to noninvasively monitoring bleeding rates.

Original language	English (US)
Title of host publication	2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages	660-663
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2011.0160
State	Published - 2011
Event	2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States Duration: Oct 18 2011 → Oct 21 2011

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Other

Other	2011 IEEE International Ultrasonics Symposium, IUS 2011
Country/Territory	United States
City	Orlando, FL
Period	10/18/11 → 10/21/11

Keywords

Acoustic Radiation Force Impulse (ARFI) ultrasound
bleeding rate
dog model
femoral arteriotomy
hemophilia
subcutaneous bleeding
von Willebrand disease

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2011.0160

Cite this

Scola, M. R., Baggesen, L. M., Behler, R. H., Nichols, T. C., Zhu, H., Caughey, M. C., Merricks, E. P., Raymer, R. A., Margaritis, P., High, K. A., & Gallippi, C. M. (2011). In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound. In 2011 IEEE International Ultrasonics Symposium, IUS 2011 (pp. 660-663). Article 6293254 (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2011.0160

In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound. / Scola, Mallory R.; Baggesen, Leslie M.; Behler, Russel H. et al.
2011 IEEE International Ultrasonics Symposium, IUS 2011. 2011. p. 660-663 6293254 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Scola, MR, Baggesen, LM, Behler, RH, Nichols, TC, Zhu, H, Caughey, MC, Merricks, EP, Raymer, RA, Margaritis, P, High, KA & Gallippi, CM 2011, In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound. in 2011 IEEE International Ultrasonics Symposium, IUS 2011., 6293254, IEEE International Ultrasonics Symposium, IUS, pp. 660-663, 2011 IEEE International Ultrasonics Symposium, IUS 2011, Orlando, FL, United States, 10/18/11. https://doi.org/10.1109/ULTSYM.2011.0160

@inproceedings{f157db9f8db5483c9e66ba1e56ac76e3,

title = "In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound",

abstract = "There is currently no validated method for assessing hemostasis in vivo. Such a method would facilitate the development of therapeutic clotting factor replacement products for patients with bleeding disorders as well as improve patient care and reduce complications following invasive procedures. We have investigated the use of Acoustic Radiation Force Impulse (ARFI) imaging as a method for assessing bleeding rate in vivo in dog models of inherited bleeding disorders and in human volunteers following arteriotomy for diagnostic percutaneous cardiac catheterization. Our data showed significantly higher bleeding rates in the VWD dogs consistent with the inherited bleeding phenotype. We also saw slower arteriotomy bleeding rates after 5 minutes when a hemostatic dressing is used to augment manual compression. These results suggest that ARFI imaging is relevant to noninvasively monitoring bleeding rates.",

keywords = "Acoustic Radiation Force Impulse (ARFI) ultrasound, bleeding rate, dog model, femoral arteriotomy, hemophilia, subcutaneous bleeding, von Willebrand disease",

author = "Scola, {Mallory R.} and Baggesen, {Leslie M.} and Behler, {Russel H.} and Nichols, {Timothy C.} and Hongtu Zhu and Caughey, {Melissa C.} and Merricks, {Elizabeth P.} and Raymer, {Robin A.} and Paris Margaritis and High, {Katherine A.} and Gallippi, {Caterina M.}",

year = "2011",

doi = "10.1109/ULTSYM.2011.0160",

language = "English (US)",

isbn = "9781457712531",

series = "IEEE International Ultrasonics Symposium, IUS",

pages = "660--663",

booktitle = "2011 IEEE International Ultrasonics Symposium, IUS 2011",

}

TY - GEN

T1 - In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound

AU - Scola, Mallory R.

AU - Baggesen, Leslie M.

AU - Behler, Russel H.

AU - Nichols, Timothy C.

AU - Zhu, Hongtu

AU - Caughey, Melissa C.

AU - Merricks, Elizabeth P.

AU - Raymer, Robin A.

AU - Margaritis, Paris

AU - High, Katherine A.

AU - Gallippi, Caterina M.

PY - 2011

Y1 - 2011

N2 - There is currently no validated method for assessing hemostasis in vivo. Such a method would facilitate the development of therapeutic clotting factor replacement products for patients with bleeding disorders as well as improve patient care and reduce complications following invasive procedures. We have investigated the use of Acoustic Radiation Force Impulse (ARFI) imaging as a method for assessing bleeding rate in vivo in dog models of inherited bleeding disorders and in human volunteers following arteriotomy for diagnostic percutaneous cardiac catheterization. Our data showed significantly higher bleeding rates in the VWD dogs consistent with the inherited bleeding phenotype. We also saw slower arteriotomy bleeding rates after 5 minutes when a hemostatic dressing is used to augment manual compression. These results suggest that ARFI imaging is relevant to noninvasively monitoring bleeding rates.

AB - There is currently no validated method for assessing hemostasis in vivo. Such a method would facilitate the development of therapeutic clotting factor replacement products for patients with bleeding disorders as well as improve patient care and reduce complications following invasive procedures. We have investigated the use of Acoustic Radiation Force Impulse (ARFI) imaging as a method for assessing bleeding rate in vivo in dog models of inherited bleeding disorders and in human volunteers following arteriotomy for diagnostic percutaneous cardiac catheterization. Our data showed significantly higher bleeding rates in the VWD dogs consistent with the inherited bleeding phenotype. We also saw slower arteriotomy bleeding rates after 5 minutes when a hemostatic dressing is used to augment manual compression. These results suggest that ARFI imaging is relevant to noninvasively monitoring bleeding rates.

KW - Acoustic Radiation Force Impulse (ARFI) ultrasound

KW - bleeding rate

KW - dog model

KW - femoral arteriotomy

KW - hemophilia

KW - subcutaneous bleeding

KW - von Willebrand disease

UR - http://www.scopus.com/inward/record.url?scp=84869035231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869035231&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2011.0160

DO - 10.1109/ULTSYM.2011.0160

M3 - Conference contribution

AN - SCOPUS:84869035231

SN - 9781457712531

T3 - IEEE International Ultrasonics Symposium, IUS

SP - 660

EP - 663

BT - 2011 IEEE International Ultrasonics Symposium, IUS 2011

T2 - 2011 IEEE International Ultrasonics Symposium, IUS 2011

Y2 - 18 October 2011 through 21 October 2011

ER -

In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this