In vivo hemostasis detection at human femoral arteriotomy by ARFI ultrasound

Russell H. Behler, Mallory R. Scola, Timothy Nichols, Melissa Caughey, Hongtu Zhu, Caterina M. Gallippi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Noninvasively monitoring hemostasis at femoral artery puncture sites (arteriotomies) could reduce complications associated with percutaneous coronary artery catheterization and reduce medical cost, yet no diagnostic imaging method is proven for this application. In a pilot clinical investigation, ARFI imaging was performed at the femoral arteriotomies of 20 patient volunteers randomized to treatment with standard of care manual compression alone or to manual compression augmented by a hemostatic dressing to expedite time to hemostasis onset. Average ARFIderived times to hemostasis in patient volunteers treated with manual compression alone (n=10) and manual compression augmented by hemostatic dressing (n=9) were, respectively, 13.00 ± 1.56 and 9.44 ± 3.09 min (p ≤ 0.0065, Wilcoxon). ARFI-induced displacements were observed to be larger at arteriotomies and in extravasated blood pools. These data suggest that ARFI imaging is capable of noninvasively monitoring hemostasis onset at femoral arteriotomies.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1879-1882
Number of pages4
ISBN (Print)9781424443895
DOIs
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
Country/TerritoryItaly
CityRome
Period9/20/099/23/09

Keywords

  • Acoustic Radiation Force Impulse (ARFI) ultrasound
  • Arteriotomy
  • Bleeding
  • Femoral artery
  • Hemostasis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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