Abstract
Cervical cancer incidence and mortality rates remain high in medically underserved areas. In this study, we present a low-cost (<$5,000), portable and user-friendly confocal microendoscope, and we report on its clinical use to image precancerous lesions in the cervix. The confocal microendoscope employs digital apertures on a digital light projector and a CMOS sensor to implement line-scanning confocal imaging. Leveraging its versatile programmability, we describe an automated aperture alignment algorithm to ensure clinical ease-of-use and to facilitate technology dissemination in low-resource settings. Imaging performance is then evaluated in ex vivo and in vivo pilot studies; results demonstrate that the confocal microendoscope can enhance visualization of nuclear morphology, contributing to significantly improved recognition of clinically important features for detection of cervical precancer.
Original language | English (US) |
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Pages (from-to) | 269-280 |
Number of pages | 12 |
Journal | Biomedical Optics Express |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - 2020 |
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics