In vivo imaging of microcirculation using integrated photoacoustic and optical coherence microscopy

Li Li; Konstantin I. Maslov; Geng Ku; Lihong V. Wang

doi:10.1117/12.809323

In vivo imaging of microcirculation using integrated photoacoustic and optical coherence microscopy

Li Li, Konstantin I. Maslov, Geng Ku, Lihong V. Wang

Cancer Systems Imaging

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.

Original language	English (US)
Article number	71770I
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7177
DOIs	https://doi.org/10.1117/12.809323
State	Published - 2009
Event	Photons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States Duration: Jan 25 2009 → Jan 28 2009

Keywords

Microcirculation
Microscopy
Multi-modality imaging
Optical coherence tomography
Photoacoustic

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.809323

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title = "In vivo imaging of microcirculation using integrated photoacoustic and optical coherence microscopy",

abstract = "Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.",

keywords = "Microcirculation, Microscopy, Multi-modality imaging, Optical coherence tomography, Photoacoustic",

author = "Li Li and Maslov, {Konstantin I.} and Geng Ku and Wang, {Lihong V.}",

year = "2009",

doi = "10.1117/12.809323",

language = "English (US)",

volume = "7177",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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note = "Photons Plus Ultrasound: Imaging and Sensing 2009 ; Conference date: 25-01-2009 Through 28-01-2009",

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TY - JOUR

T1 - In vivo imaging of microcirculation using integrated photoacoustic and optical coherence microscopy

AU - Li, Li

AU - Maslov, Konstantin I.

AU - Ku, Geng

AU - Wang, Lihong V.

PY - 2009

Y1 - 2009

N2 - Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.

AB - Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.

KW - Microcirculation

KW - Microscopy

KW - Multi-modality imaging

KW - Optical coherence tomography

KW - Photoacoustic

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M3 - Conference article

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VL - 7177

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 71770I

T2 - Photons Plus Ultrasound: Imaging and Sensing 2009

Y2 - 25 January 2009 through 28 January 2009

ER -

In vivo imaging of microcirculation using integrated photoacoustic and optical coherence microscopy

Abstract

Keywords

ASJC Scopus subject areas

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