In vivo respiratory-gated micro-CT imaging in small-animal oncology models

Dawn Cavanaugh; Evan Johnson; Roger E. Price; Jonathan Kurie; Elizabeth L. Travis; Dianna D. Cody

doi:10.1162/153535004773861723

In vivo respiratory-gated micro-CT imaging in small-animal oncology models

Dawn Cavanaugh, Evan Johnson, Roger E. Price, Jonathan Kurie, Elizabeth L. Travis, Dianna D. Cody

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

Micro-computed tomography (micro-CT) is becoming an accepted research tool for the noninvasive examination of laboratory animals such as mice and rats, but to date, in vivo scanning has largely been limited to the evaluation of skeletal tissues. We use a commercially available micro-CT device to perform respiratory gated in vivo acquisitions suitable for thoracic imaging. The instrument is described, along with the scan protocol and animal preparation techniques. Preliminary results confirm that lung tumors as small as 1 mm in diameter are visible in vivo with these methods. Radiation dose was evaluated using several approaches, and was found to be approximately 0.15 Gy for this respiratory-gated micro-CT imaging protocol. The combination of high-resolution CT imaging and respiratory-gated acquisitions appears well-suited to serial in vivo scanning.

Original language	English (US)
Pages (from-to)	55-62
Number of pages	8
Journal	Molecular imaging
Volume	3
Issue number	1
DOIs	https://doi.org/10.1162/153535004773861723
State	Published - Jan 2004

Keywords

Cone-beam CT
In vivo
Lungs
Micro-CT
Respiratory gating

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Biomedical Engineering
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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abstract = "Micro-computed tomography (micro-CT) is becoming an accepted research tool for the noninvasive examination of laboratory animals such as mice and rats, but to date, in vivo scanning has largely been limited to the evaluation of skeletal tissues. We use a commercially available micro-CT device to perform respiratory gated in vivo acquisitions suitable for thoracic imaging. The instrument is described, along with the scan protocol and animal preparation techniques. Preliminary results confirm that lung tumors as small as 1 mm in diameter are visible in vivo with these methods. Radiation dose was evaluated using several approaches, and was found to be approximately 0.15 Gy for this respiratory-gated micro-CT imaging protocol. The combination of high-resolution CT imaging and respiratory-gated acquisitions appears well-suited to serial in vivo scanning.",

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AU - Price, Roger E.

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AU - Travis, Elizabeth L.

AU - Cody, Dianna D.

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In vivo respiratory-gated micro-CT imaging in small-animal oncology models

Abstract

Keywords

ASJC Scopus subject areas

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