TY - JOUR
T1 - Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract
T2 - A Multi-Institutional Comparative Study
AU - Valdés Zayas, Anet
AU - Kumari, Neeraj
AU - Liu, Kevin
AU - Neill, Denae
AU - Delahoussaye, Abagail
AU - Gonçalves Jorge, Patrik
AU - Geyer, Reiner
AU - Lin, Steven H.
AU - Bailat, Claude
AU - Bochud, François
AU - Moeckli, Raphael
AU - Koong, Albert C.
AU - Bourhis, Jean
AU - Taniguchi, Cullen M.
AU - Herrera, Fernanda G.
AU - Schüler, Emil
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH Mobetron system. The two centers used similar beam parameters but otherwise conducted the studies independently. The FLASH-enabled animal survival and intestinal crypt regeneration after irradiation were comparable between the two centers. These findings, together with previously published data using a converted linear accelerator, show that a robust and reproducible FLASH effect can be induced as long as the same set of irradiation parameters are used.
AB - FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH Mobetron system. The two centers used similar beam parameters but otherwise conducted the studies independently. The FLASH-enabled animal survival and intestinal crypt regeneration after irradiation were comparable between the two centers. These findings, together with previously published data using a converted linear accelerator, show that a robust and reproducible FLASH effect can be induced as long as the same set of irradiation parameters are used.
KW - crypt assay
KW - FLASH
KW - gastrointestinal toxicity
KW - multi-institutional
KW - radiation oncology
KW - radiation response
KW - radiation therapy
KW - ultra-high dose rate
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U2 - 10.3390/cancers15072121
DO - 10.3390/cancers15072121
M3 - Article
C2 - 37046782
AN - SCOPUS:85152944187
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 7
M1 - 2121
ER -