@article{d30ea245464949e3b93ec93e5db0065e,
title = "Induction of multi-epitope-specific antibodies against HIV-1 by multi-epitope-vaccines",
abstract = "Some neutralizing antibodies against HIV-1 envelope proteins were highly effective to inhibit the infection of different strains in vitro, and existed in the infected individuals with very low levels. We suggested multi-epitope-vaccine as a new strategy to increase levels of neutralizing antibodies and the abilities against HIV mutation in vivo. Two candidate multi-epitope-vaccines induced anti-bodies with predefined multi-epitope-specificity in rhesus macaque. These antibodies recognized corresponding neutralizing epitopes on epitope-peptides, gp41 peptides, V3 loop peptide, rsgp41 and rgp120. Besides, three candidate epitope-vaccines in combination (another kind of multi-epitope-vaccines) showed similar potency to induce predefined multiple immune responses in rabbits. These results suggest that multi-epitope-vaccines may be a new strategy to induce multi-antiviral activities against HIV-1 infection and mutations.",
keywords = "HIV-1, Multi-epitope-vaccine, Neutralizing epitope",
author = "J. Ding and F. He and Y. Lu and Y. Xiao and Y. Chen",
note = "Funding Information: Acknowledgements This work was supported by the National Key Funding Information: Basic Research Specific Funds (Grant No. G1999054107) and the National Science Foundation for Outstanding Young Scientists of China (Grant No. 30025038). References 1. Connor, R. I., Korber, B. T. M., Graham, B. S. et al., Immunological and virological analyses of persons infected by human-immunodeficiency-virus type-1 while participating in trials of recombinant gp120 subunit vaccines, J. Virol., 1998, 72: 1552. 2. Muster, T., Steindl, F., Purtscher, M., A conserved neutralizing epitope on gp41 of human immunodeficiency virus type I, J. Vi-rol., 1993, 67: 6642. 3. Moore, J. P., Burton, D. R., HIV-1 neutralizing antibodies: How full is the bottle? Nature Med., 1999, 5: 142. 4. Chen, Y. H., Xiao, Y., Yu, T. W. et al., Epitope-vaccine: a new strategy against HIV-1, Immunology Today, 1999, 20: 588. 5. Igarashi, T., Brown, C., Azadegan, A. et al., Human immunodeficiency yirus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma, Nature Med., 1999, 5: 211.",
year = "2001",
doi = "10.1007/BF02901157",
language = "English (US)",
volume = "46",
pages = "1859--1864",
journal = "Chinese Science Bulletin",
issn = "1001-6538",
publisher = "Springer Science + Business Media",
number = "22",
}