@article{4cc1fb3817624ecbb228a1e889c7a031,
title = "Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer",
abstract = "Background: The aim of this study was to investigate the relationship between high-risk genotypes of Human Papilloma Virus (HPV) and cancer of different subsites of the oral cavity. Material and methods: A pooled analysis of five studies included on the International Head and Neck Cancer Epidemiology (INHANCE) Consortium was conducted. HPV 16 and HPV 18 were considered. Adjusted odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) for HPV and each oral cavity subsites were simultaneously estimated using multinomial logistic regression models. Results: The analysis included 1157 cases and 3272 controls. This study showed a slightly higher prevalence of HPV infection among oral cancer cases than controls. In particular, an increased risk of other and not otherwise specified (NOS) sites within the oral cavity, oral tongue, palate and floor of mouth cancer was observed for overall HPV16 positivity (OR = 1.66, 95 % CI: 1.01−2.72; OR = 1.97, 95 % CI: 1.36−2.85; OR = 2.48, 95 % CI: 1.50−4.11; OR = 2.71, 95 % CI: 1.06−6.95, respectively). In particular, HPV16E7 was related to cancer of floor of mouth, oral cavity NOS and palate (OR = 2.71, 95 % CI: 1.06−6.95; OR = 3.32, 95 % CI:1.53−7.19; OR = 3.34, 95 % CI:1.38−8.06). Results were inconsistent for HPV18 due to low prevalence of infection. Conclusion: Our study suggests that HPV16 infection may increase the risk of developing floor of mouth, gum, tongue, and palate cancers. Clinical relevance: Subjects with HPV infection have a higher risk of cancer from all sites of the oral cavity.",
keywords = "Floor of mouth, Gum, Human papilloma virus, Oral cancer, Oral cavity, Palate, Tongue",
author = "Luca Giraldi and Giulia Collatuzzo and Dana Hashim and Silvia Franceschi and Rolando Herrero and Chu Chen and Schwartz, {Stephen M.} and Elaine Smith and Karl Kelsey and Michael McClean and Maura Gillison and Stefania Boccia and Mia Hashibe and {Amy Lee}, {Yuan Chin} and Paolo Boffetta",
note = "Funding Information: The pooled data coordination team were supported by National Cancer Institute grant R03CA113157and by National Institute of Dental and Craniofacial Research grantR03DE016611. The IARC Multicenter study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [FIS 97/ 0024, FIS 97/0662, BAE 01/5013], International Union Against Cancer (UICC), and Yamagiwa-Yoshida Memorial International Cancer Study Grant. The Seattle study was funded by NIH [R01CA048996,R01DE012609]. The Iowa study was funded by NIH [NIDCRR01DE011979, NIDCRR01DE013110, NIH FIRCATW001500] and Veterans Affairs Merit Review Funds. The Boston study was funded by NIH [R01CA078609, R01CA100679]. The Baltimore study was funded by NIH [DE016631]. Funding Information: The pooled data coordination team were supported by National Cancer Institute grant R03CA113157 and by National Institute of Dental and Craniofacial Research grant R03DE016611 . The IARC Multicenter study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [ FIS 97/ 0024 , FIS 97/0662 , BAE 01/5013 ], International Union Against Cancer (UICC) , and Yamagiwa-Yoshida Memorial International Cancer Study Grant. The Seattle study was funded by NIH [ R01CA048996 , R01DE012609 ]. The Iowa study was funded by NIH [NIDCR R01DE011979, NIDCR R01DE013110 , NIH FIRCA TW001500 ] and Veterans Affairs Merit Review Funds . The Boston study was funded by NIH [ R01CA078609 , R01CA100679 ]. The Baltimore study was funded by NIH [ DE016631 ]. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = dec,
doi = "10.1016/j.canep.2021.102020",
language = "English (US)",
volume = "75",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
}