TY - JOUR
T1 - Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation
AU - Asano, Hinami
AU - Hasegawa-Ishii, Sanae
AU - Arae, Ken
AU - Obara, Aki
AU - Laumet, Geoffroy
AU - Dantzer, Robert
AU - Shimada, Atsuyoshi
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Chronic nasal inflammation induces robust olfactory bulb (OB) atrophy in mice. Here we examined initial events that occur in the OB after bilateral intranasal administration of lipopolysaccharide, focusing on the olfactory nerve fibers and meninges. We analyzed the time course of OB and meninges inflammation using histological and biochemical approaches. Within 12 h, we observed increased chemokine expression and transient infiltration of peripheral immune cells into the OB, resulting in the development of pro-inflammatory status in the OB. Meningeal immunity was activated. Resident microglia produced anti-inflammatory cytokines within 24 h. These could be the initial events that lead to OB atrophy.
AB - Chronic nasal inflammation induces robust olfactory bulb (OB) atrophy in mice. Here we examined initial events that occur in the OB after bilateral intranasal administration of lipopolysaccharide, focusing on the olfactory nerve fibers and meninges. We analyzed the time course of OB and meninges inflammation using histological and biochemical approaches. Within 12 h, we observed increased chemokine expression and transient infiltration of peripheral immune cells into the OB, resulting in the development of pro-inflammatory status in the OB. Meningeal immunity was activated. Resident microglia produced anti-inflammatory cytokines within 24 h. These could be the initial events that lead to OB atrophy.
KW - Meninges
KW - Nasal inflammation
KW - Olfactory bulb
KW - Olfactory nerve fibers
KW - Peripheral immune cells
KW - Resident microglia
UR - http://www.scopus.com/inward/record.url?scp=85131122739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131122739&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2022.577897
DO - 10.1016/j.jneuroim.2022.577897
M3 - Article
C2 - 35661951
AN - SCOPUS:85131122739
SN - 0165-5728
VL - 368
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577897
ER -