Inflammation and melanoma metastasis

Vladislava O. Melnikova; Menashe Bar-Eli

doi:10.1111/j.1755-148X.2009.00570.x

Inflammation and melanoma metastasis

Vladislava O. Melnikova, Menashe Bar-Eli

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Metastatic melanoma is extremely refractory to existing chemotherapeutic drugs and bioimmune adjuvant therapies, and the life span of patients with metastatic melanoma is often measured in months. Understanding the mechanisms responsible for the development of tumor metastasis is critical for finding successful curative measures. An expending amount of data reveal the importance of inflammatory microenvironment and stroma in cancer initiation and progression, which brings new directions and approaches to cancer treatment. This review will summarize current data on the role of the tumor microenvironment in shaping the metastatic phenotype of melanoma.

Original language	English (US)
Pages (from-to)	257-267
Number of pages	11
Journal	Pigment Cell and Melanoma Research
Volume	22
Issue number	3
DOIs	https://doi.org/10.1111/j.1755-148X.2009.00570.x
State	Published - Jun 2009

Keywords

Melanoma
Metastasis
Microenvironment
PAR1
Platelet-activating factor
Platelets
Thrombin receptor
Tumor

ASJC Scopus subject areas

Oncology
General Biochemistry, Genetics and Molecular Biology
Dermatology

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10.1111/j.1755-148X.2009.00570.x

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AU - Bar-Eli, Menashe

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AB - Metastatic melanoma is extremely refractory to existing chemotherapeutic drugs and bioimmune adjuvant therapies, and the life span of patients with metastatic melanoma is often measured in months. Understanding the mechanisms responsible for the development of tumor metastasis is critical for finding successful curative measures. An expending amount of data reveal the importance of inflammatory microenvironment and stroma in cancer initiation and progression, which brings new directions and approaches to cancer treatment. This review will summarize current data on the role of the tumor microenvironment in shaping the metastatic phenotype of melanoma.

KW - Melanoma

KW - Metastasis

KW - Microenvironment

KW - PAR1

KW - Platelet-activating factor

KW - Platelets

KW - Thrombin receptor

KW - Tumor

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Inflammation and melanoma metastasis

Abstract

Keywords

ASJC Scopus subject areas

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