TY - JOUR
T1 - Inflammation and pro-resolution inflammation after hepatobiliary surgery
AU - Cata, Juan P.
AU - Velasquez, Jose F.
AU - Ramirez, Maria F.
AU - Vauthey, Jean Nicolas
AU - Gottumukkala, Vijaya
AU - Conrad, Claudius
AU - Kim, Bradford J.
AU - Aloia, Thomas
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/8/10
Y1 - 2017/8/10
N2 - Background: The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. Methods: All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5. Interleukin-6, cortisol, lipoxin-A4, and resolvin D were measured in plasma. A P value < 0.05 was considered statistically significant. Results: Forty-one patients were included in the study. Liver resection for colorectal metastatic disease was the most commonly performed surgery. The plasma concentrations of interleukin-6 were highest on day 1 after surgery and remained higher than the baseline up to postoperative day 1. Postoperative complications occurred in 14 (24%) patients. Cortisol concentrations spiked on postoperative day 1. The concentrations of lipoxin A4 and resolvin D were lowest on day 1 after surgery. Conclusions: The inflammatory response associated with hepatobiliary surgery is associated with low circulating concentrations of lipoxin A4 and resolvin D that mirror, in an opposite manner, the kinetics of interleukin 6 and cortisol.
AB - Background: The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. Methods: All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5. Interleukin-6, cortisol, lipoxin-A4, and resolvin D were measured in plasma. A P value < 0.05 was considered statistically significant. Results: Forty-one patients were included in the study. Liver resection for colorectal metastatic disease was the most commonly performed surgery. The plasma concentrations of interleukin-6 were highest on day 1 after surgery and remained higher than the baseline up to postoperative day 1. Postoperative complications occurred in 14 (24%) patients. Cortisol concentrations spiked on postoperative day 1. The concentrations of lipoxin A4 and resolvin D were lowest on day 1 after surgery. Conclusions: The inflammatory response associated with hepatobiliary surgery is associated with low circulating concentrations of lipoxin A4 and resolvin D that mirror, in an opposite manner, the kinetics of interleukin 6 and cortisol.
KW - Complications
KW - Hepatobiliary surgery
KW - Inflammation
KW - Resolution
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U2 - 10.1186/s12957-017-1220-6
DO - 10.1186/s12957-017-1220-6
M3 - Article
C2 - 28807031
AN - SCOPUS:85027286205
SN - 1477-7819
VL - 15
JO - World journal of surgical oncology
JF - World journal of surgical oncology
IS - 1
M1 - 152
ER -