TY - JOUR
T1 - Inflammation-induced motivational changes
T2 - perspective gained by evaluating positive and negative valence systems
AU - Vichaya, Elisabeth G.
AU - Dantzer, Robert
N1 - Funding Information:
This research was supported by the National Institutes of Health ( R01 CA193522 and R21 MH104694 to R. Dantzer as well as an MD Anderson Cancer Center Support Grant , P30 CA016672 ).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/8
Y1 - 2018/8
N2 - Inflammation can profoundly impact motivated behavior, as is the case with inflammation-induced depression. By evaluating objectively measurable basic neurobehavioral processes involved in motivation, recent research indicates that inflammation generally reduces approach motivation and enhances avoidance motivation. Increased effort valuation largely mediates the effects of inflammation on approach motivation. Changes in reward valuation are not uniformly observed in approach motivation. However, inflammation increases the averseness of negative stimuli. Within the context of both approach and avoidance motivation, inflammation appears to enhance the contrast between concurrently presented stimuli. While changes in both approach and avoidance motivation appear to be mediated by midbrain dopaminergic neurotransmission to the ventral striatum, it is unclear if the enhanced contrast is mediated by the same system.
AB - Inflammation can profoundly impact motivated behavior, as is the case with inflammation-induced depression. By evaluating objectively measurable basic neurobehavioral processes involved in motivation, recent research indicates that inflammation generally reduces approach motivation and enhances avoidance motivation. Increased effort valuation largely mediates the effects of inflammation on approach motivation. Changes in reward valuation are not uniformly observed in approach motivation. However, inflammation increases the averseness of negative stimuli. Within the context of both approach and avoidance motivation, inflammation appears to enhance the contrast between concurrently presented stimuli. While changes in both approach and avoidance motivation appear to be mediated by midbrain dopaminergic neurotransmission to the ventral striatum, it is unclear if the enhanced contrast is mediated by the same system.
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U2 - 10.1016/j.cobeha.2018.01.008
DO - 10.1016/j.cobeha.2018.01.008
M3 - Review article
C2 - 29888301
AN - SCOPUS:85041722107
SN - 2352-1546
VL - 22
SP - 90
EP - 95
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
ER -