TY - JOUR
T1 - Inflammatory breast cancer survival
T2 - The role of obesity and menopausal status at diagnosis
AU - Chang, S.
AU - Alderfer, J. R.
AU - Asmar, L.
AU - Buzdar, A. U.
N1 - Funding Information:
We would like to thank Nancy Russell and Sarah Taylor of the Department of Medical Infomatics, Debra Frye of the Department of Breast Medical Oncology, Yuko Yamamura and Qing Zhang of the Department of Epidemiology at The University of Texas M.D. Anderson Cancer Center for their assistance with data collection and manuscript preparation. We would also like to thank Dr Maureen Goode of the Department of Scientific Publications and Drs Margaret R. Spitz, Alice Sigurdson, Sarah Tropman, and Randa El-Zien of the Department of Epidemiology for their helpful editorial comments. We also thank Ms. Rona M. McDonald and Diane Reina of the Department of Medical Graphics and Photography for her assistance with illustrations and Mr. Mark Van Roten of Research Information Systems for his assistance with Reference Manager. Dr Chang and this work are supported by the American Cancer Society, the M. D. Anderson Breast Cancer Research Group the Cancer Research Foundation of America, and generous donors from the IBC Help Page Web Site (http://www.bestiary.com/ibc/index.html).
PY - 2000
Y1 - 2000
N2 - No previous studies have evaluated the effect of body size and menopausal status at diagnosis on survival from inflammatory breast cancer (IBC). We evaluated whether obesity and menopausal status had an impact on IBC survival in a cohort of 177 female IBC patients seen from 1974 to 1993 at The University of Texas MD Anderson Cancer Center. Survival time was defined as time from diagnosis until death or censorship at last date of contact. We categorized women by body size by using the National Institutes of Health/National Heart, Lung, and Blood Institute's definitions of obesity as body mass index ((BMI) = weight in kg/(height in m)2) ≥ 30, overweight as 25 ≤ BMI < 30 kg/m2, and normal/lean as BMI <25 kg/m2. Cox proportional hazards analysis, adjusting for axillary lymph node involvement and chemotherapy protocol, revealed a modifying effect of menopausal status at diagnosis on the association between obesity and IBC survival (P = 0.02). Relative to postmenopausal women, premenopausal women had significantly worse survival (hazard ratio (HR) = 1.51, 95% confidence interval (CI) = 1.03-2.22). After stratifying by menopausal status, premenopausal obese women had non-significantly better survival than their leaner premenopausal counterparts (HR = 0.63, 95% CI = 0.34-1.15) while postmenopausal obese women had significantly worse survival than their leaner counterparts (HR = 1.86, 95% CI = 1.02-3.40). These findings suggest that factors associated with larger body size at diagnosis may contribute to shorter IBC survival among postmenopausal women but not premenopausal women, who were found to have poorer survival regardless of body size.
AB - No previous studies have evaluated the effect of body size and menopausal status at diagnosis on survival from inflammatory breast cancer (IBC). We evaluated whether obesity and menopausal status had an impact on IBC survival in a cohort of 177 female IBC patients seen from 1974 to 1993 at The University of Texas MD Anderson Cancer Center. Survival time was defined as time from diagnosis until death or censorship at last date of contact. We categorized women by body size by using the National Institutes of Health/National Heart, Lung, and Blood Institute's definitions of obesity as body mass index ((BMI) = weight in kg/(height in m)2) ≥ 30, overweight as 25 ≤ BMI < 30 kg/m2, and normal/lean as BMI <25 kg/m2. Cox proportional hazards analysis, adjusting for axillary lymph node involvement and chemotherapy protocol, revealed a modifying effect of menopausal status at diagnosis on the association between obesity and IBC survival (P = 0.02). Relative to postmenopausal women, premenopausal women had significantly worse survival (hazard ratio (HR) = 1.51, 95% confidence interval (CI) = 1.03-2.22). After stratifying by menopausal status, premenopausal obese women had non-significantly better survival than their leaner premenopausal counterparts (HR = 0.63, 95% CI = 0.34-1.15) while postmenopausal obese women had significantly worse survival than their leaner counterparts (HR = 1.86, 95% CI = 1.02-3.40). These findings suggest that factors associated with larger body size at diagnosis may contribute to shorter IBC survival among postmenopausal women but not premenopausal women, who were found to have poorer survival regardless of body size.
KW - Inflammatory breast cancer
KW - Obesity
KW - Postmenopausal
KW - Premenopausal
KW - Survival
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U2 - 10.1023/A:1006489100283
DO - 10.1023/A:1006489100283
M3 - Article
C2 - 11194451
AN - SCOPUS:0034538349
SN - 0167-6806
VL - 64
SP - 157
EP - 163
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 2
ER -