Abstract
In search of genetic alterations responsible for high fetal hemoglobin (Hb F) phenotypes in the population of eastern India, 91 probands were screened for four polymorphisms by sequencing and/or restriction fragment length polymorphism (RFLP) analysis. These are the A>G allele on the rs4895441 locus in the intergenic region between HBS1L and MYB on chromosome 6, the G>A allele on the rs4671393 locus on chromosome 2 (BCL11A gene), the A>C allele on the rs2071348 (HBBP1 gene) and the XmnI polymorphism (rs7482144, -158 position of HBG2) on chromosome 11. We found a significant association (p = 0.002 and 0.0013) of Hb F levels with rs2071348 and rs4895441, respectively. However, the polymorphism rs4671393 gene did not show significant association with Hb F levels (p = 0.0655). As is well known, the XmnI polymorphism (p <0.0001) showed the strongest association.
Original language | English (US) |
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Pages (from-to) | 592-599 |
Number of pages | 8 |
Journal | Hemoglobin |
Volume | 36 |
Issue number | 6 |
DOIs | |
State | Published - 2012 |
Keywords
- Fetal hemoglobin (Hb F)
- HBBP1
- India
- Thalassemia
- Trans polymorphisms
ASJC Scopus subject areas
- Hematology
- Clinical Biochemistry
- Genetics(clinical)
- Biochemistry, medical