TY - JOUR
T1 - Inhalation of Isopropyl Alcohol for the Management of Nausea and Vomiting
T2 - A Systematic Review
AU - Erdogan-Ongel, Elif
AU - Heung, Yvonne
AU - Rozman De Moraes, Aline
AU - Geng, Yimin
AU - Bruera, Eduardo
N1 - Publisher Copyright:
© Copyright 2023, Mary Ann Liebert, Inc., publishers 2023.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Background: The use of inhaled isopropyl alcohol (IPA) has been proposed as a therapeutic intervention for the relief of nausea in various settings. The objective of this systematic review was to evaluate the existing evidence for the use of inhaled IPA in the management of nausea and vomiting. Methods: We performed a literature search on Medline, EMBASE, Web of Science, Scopus, CINAHL, PsycInfo, and Cochrane Library databases before November 2021. The following concepts were searched using subject headings and keywords as needed "aromatherapy,""alcohol,""ethylic alcohol,""ethanol,""isopropyl alcohol,""emesis,""chemotherapy-induced,""pregnancy,""hyperemesis gravidarum,""motion sickness,""emetics,""antiemetics,""inhalation,"and "inhale."Searches were not limited to a specific language. The bibliographies of identified articles were also manually searched. Two authors independently assessed the included studies for risk of bias. Results: Thirteen randomized controlled trials out of 158 studies identified met the inclusion criteria, with a total of 1253 participants. Twelve studies were conducted in the postoperative anesthesia care unit and two studies were performed in the emergency department setting. Four studies were double blinded, one was single blind, and eight were open label. Three studies assessed the use of inhaled IPA for prevention, whereas 10 studies evaluated its use in the treatment of nausea and vomiting. Seven studies reported IPA to be more effective, four studies reported no difference, and two studies reported IPA to be ineffective. Participant satisfaction was high overall, regardless of intervention received. No adverse effects were reported. The overall quality of evidence was low. Conclusion: There is a lack of strong evidence to support the use of inhaled IPA in the management of nausea and vomiting. Additional trials are warranted to confirm this finding and to further explore the use of inhaled IPA in various populations and settings.
AB - Background: The use of inhaled isopropyl alcohol (IPA) has been proposed as a therapeutic intervention for the relief of nausea in various settings. The objective of this systematic review was to evaluate the existing evidence for the use of inhaled IPA in the management of nausea and vomiting. Methods: We performed a literature search on Medline, EMBASE, Web of Science, Scopus, CINAHL, PsycInfo, and Cochrane Library databases before November 2021. The following concepts were searched using subject headings and keywords as needed "aromatherapy,""alcohol,""ethylic alcohol,""ethanol,""isopropyl alcohol,""emesis,""chemotherapy-induced,""pregnancy,""hyperemesis gravidarum,""motion sickness,""emetics,""antiemetics,""inhalation,"and "inhale."Searches were not limited to a specific language. The bibliographies of identified articles were also manually searched. Two authors independently assessed the included studies for risk of bias. Results: Thirteen randomized controlled trials out of 158 studies identified met the inclusion criteria, with a total of 1253 participants. Twelve studies were conducted in the postoperative anesthesia care unit and two studies were performed in the emergency department setting. Four studies were double blinded, one was single blind, and eight were open label. Three studies assessed the use of inhaled IPA for prevention, whereas 10 studies evaluated its use in the treatment of nausea and vomiting. Seven studies reported IPA to be more effective, four studies reported no difference, and two studies reported IPA to be ineffective. Participant satisfaction was high overall, regardless of intervention received. No adverse effects were reported. The overall quality of evidence was low. Conclusion: There is a lack of strong evidence to support the use of inhaled IPA in the management of nausea and vomiting. Additional trials are warranted to confirm this finding and to further explore the use of inhaled IPA in various populations and settings.
KW - alcohol
KW - aromatherapy
KW - inhalation
KW - nausea
KW - systematic review
KW - vomiting
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U2 - 10.1089/jpm.2022.0332
DO - 10.1089/jpm.2022.0332
M3 - Review article
C2 - 36178929
AN - SCOPUS:85145955293
SN - 1096-6218
VL - 26
SP - 94
EP - 100
JO - Journal of palliative medicine
JF - Journal of palliative medicine
IS - 1
ER -