Inhibition of HIV replication by liposomal encapsulated amphotericin B

D. R. Pontani; D. Sun; J. W. Brown; S. I. Shahied; O. J. Plescia; C. P. Schaffner; G. Lopez-Berestein; P. S. Sarin

doi:10.1016/0166-3542(89)90023-5

Inhibition of HIV replication by liposomal encapsulated amphotericin B

D. R. Pontani, D. Sun, J. W. Brown, S. I. Shahied, O. J. Plescia, C. P. Schaffner, G. Lopez-Berestein, P. S. Sarin

Experimental Therapeutics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibiting the growth of HIV. Virus expression was suppressed at a concentration of 5-10 μg/ml of the drugs. The liposomal preparation showed greatly reduced cytotoxicity in experiments using cultures of murine leukocytes. These results show the potential usefulness of liposomal encapsulated drugs in the treatment of patients with AIDS or AIDS related complex.

Original language	English (US)
Pages (from-to)	119-125
Number of pages	7
Journal	Antiviral Research
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0166-3542(89)90023-5
State	Published - Apr 1989

Keywords

Amphotericin B
Inhibition of HIV replication
Liposomal encapsulated drug

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/0166-3542(89)90023-5

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title = "Inhibition of HIV replication by liposomal encapsulated amphotericin B",

abstract = "This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibiting the growth of HIV. Virus expression was suppressed at a concentration of 5-10 μg/ml of the drugs. The liposomal preparation showed greatly reduced cytotoxicity in experiments using cultures of murine leukocytes. These results show the potential usefulness of liposomal encapsulated drugs in the treatment of patients with AIDS or AIDS related complex.",

keywords = "Amphotericin B, Inhibition of HIV replication, Liposomal encapsulated drug",

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T1 - Inhibition of HIV replication by liposomal encapsulated amphotericin B

AU - Pontani, D. R.

AU - Sun, D.

AU - Brown, J. W.

AU - Shahied, S. I.

AU - Plescia, O. J.

AU - Schaffner, C. P.

AU - Lopez-Berestein, G.

AU - Sarin, P. S.

PY - 1989/4

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N2 - This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibiting the growth of HIV. Virus expression was suppressed at a concentration of 5-10 μg/ml of the drugs. The liposomal preparation showed greatly reduced cytotoxicity in experiments using cultures of murine leukocytes. These results show the potential usefulness of liposomal encapsulated drugs in the treatment of patients with AIDS or AIDS related complex.

AB - This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibiting the growth of HIV. Virus expression was suppressed at a concentration of 5-10 μg/ml of the drugs. The liposomal preparation showed greatly reduced cytotoxicity in experiments using cultures of murine leukocytes. These results show the potential usefulness of liposomal encapsulated drugs in the treatment of patients with AIDS or AIDS related complex.

KW - Amphotericin B

KW - Inhibition of HIV replication

KW - Liposomal encapsulated drug

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Inhibition of HIV replication by liposomal encapsulated amphotericin B

Abstract

Keywords

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