Inhibition of human leukocyte migration in agarose by KCl extracts of lung cancer

It is demonstrated that lung tumor associated antigens can be solubilized and that these antigens elicit specific delayed cutaneous hypersensitivity reactions in vivo and specifically inhibit leukocyte migration in vitro. The fact that in 2 patients specific reactivity was present to their own autologous tumor but not to autologous normal lung suggests the presence of a lung tumor antigen. However, the occasional inhibition of migration by extracts of normal lung tissue leaves open the possibility that one is detecting a tissue specific antigen present in greater quantity on malignant cells. The finding of specific reactivity to allogeneic tumor extracts but not to extracts of the corresponding normal lung suggests the possibility of common lung tumor antigens.