Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids

Johannes F. Fahrmann; Oscar F. Ballester; Gabriela Ballester; Theodore R. Witte; Alexander J. Salazar; Benjamin Kordusky; Kelsey G. Cowen; Gabriela Ion; Donald A. Primerano; Goran Boskovic; James Denvir; W. Elaine Hardman

doi:10.3109/07357907.2012.743553

Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids

Johannes F. Fahrmann, Oscar F. Ballester, Gabriela Ballester, Theodore R. Witte, Alexander J. Salazar, Benjamin Kordusky, Kelsey G. Cowen, Gabriela Ion, Donald A. Primerano, Goran Boskovic, James Denvir, W. Elaine Hardman

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g n-3/day. After n-3 consumption: 1) plasma n-3 increased; 2) NFκB activation was suppressed in lymphocytes; 3) in vitro sensitivity of lymphocytes to doxorubicin was increased; and 4) expression of 32 genes in lymphocytes was significantly decreased.

Original language	English (US)
Pages (from-to)	24-38
Number of pages	15
Journal	Cancer Investigation
Volume	31
Issue number	1
DOIs	https://doi.org/10.3109/07357907.2012.743553
State	Published - Jan 2013
Externally published	Yes

Keywords

Cancer prevention
Clinical trials
Leukemias

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3109/07357907.2012.743553

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Fahrmann, J. F., Ballester, O. F., Ballester, G., Witte, T. R., Salazar, A. J., Kordusky, B., Cowen, K. G., Ion, G., Primerano, D. A., Boskovic, G., Denvir, J., & Hardman, W. E. (2013). Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids. Cancer Investigation, 31(1), 24-38. https://doi.org/10.3109/07357907.2012.743553

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abstract = "Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g n-3/day. After n-3 consumption: 1) plasma n-3 increased; 2) NFκB activation was suppressed in lymphocytes; 3) in vitro sensitivity of lymphocytes to doxorubicin was increased; and 4) expression of 32 genes in lymphocytes was significantly decreased.",

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AU - Witte, Theodore R.

AU - Salazar, Alexander J.

AU - Kordusky, Benjamin

AU - Cowen, Kelsey G.

AU - Ion, Gabriela

AU - Primerano, Donald A.

AU - Boskovic, Goran

AU - Denvir, James

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Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids

Abstract

Keywords

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