Abstract
Background: Various fragments of the fibrinolytic protein plasminogen can act as antiangiogenic factors and inhibit the growth of primary and metastatic tumors in mice. Plasminogen-related gene-B encodes a putative 9 kDa protein virtually identical to the plasminogen N-terminal activation peptide, a 77-amino acid motif that is liberated from the parent plasminogen molecule during conversion to the serine proteinase plasmin. Previous data have documented enhanced transcription of plasminogen-related gene-B in neoplastic tissues. Materials and Methods: We have tested the effects of recombinant versions of plasminogen-related protein-B and the plasminogen N-terminal activation peptide on the growth of tumors in mice, employing murine tumor cell lines implanted subcutaneously. Results: The recombinant plasminogen-related protein-B significantly inhibited the growth of primary tumors in mice, while recombinant plasminogen N-terminal activation peptide elicited only a slight inhibition of tumor growth. Conclusion: These data suggest that plasminogen-related protein-B may have utility as a novel cancer therapeutic.
Original language | English (US) |
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Pages (from-to) | 2287-2291 |
Number of pages | 5 |
Journal | Anticancer research |
Volume | 21 |
Issue number | 4 A |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Plasminogen-activation peptide
- Plasminogen-related protein-B
- Recombinant protein
- Tumor
ASJC Scopus subject areas
- Oncology
- Cancer Research