TY - JOUR
T1 - Injectable modalities as local and regional strategies for head and neck cancer
AU - Clayman, G. L.
AU - Dreiling, L. K.
PY - 1999
Y1 - 1999
N2 - New approaches to the treatment of head and neck cancer involve delivery of the therapeutic agent by direct injection into the tumor lesions. This locoregional therapy allows adaptation of conventional chemotherapy agents, such as bleomycin and cisplatin, to achieve higher drug concentrations in the tumor while avoiding severe systemic toxicities. Novel therapies administered through tumor injection, such as gene transfer, photosensitization, and biologic response modification, have been investigated in preclinical studies and are currently in different phases of clinical trial.
AB - New approaches to the treatment of head and neck cancer involve delivery of the therapeutic agent by direct injection into the tumor lesions. This locoregional therapy allows adaptation of conventional chemotherapy agents, such as bleomycin and cisplatin, to achieve higher drug concentrations in the tumor while avoiding severe systemic toxicities. Novel therapies administered through tumor injection, such as gene transfer, photosensitization, and biologic response modification, have been investigated in preclinical studies and are currently in different phases of clinical trial.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032856274&partnerID=8YFLogxK
U2 - 10.1016/S0889-8588(05)70093-9
DO - 10.1016/S0889-8588(05)70093-9
M3 - Article
C2 - 10494514
AN - SCOPUS:0032856274
SN - 0889-8588
VL - 13
SP - 787
EP - 810
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 4
ER -