Abstract
Subsets of long interspersed nuclear element 1 (LINE-1) retrotransposons can ‘retrotranspose’ throughout the human genome at a cost to host cell fitness, as observed in some cancers. Pharmacological inhibition of LINE-1 retrotransposition requires a comprehensive understanding of the LINE-1 ORF2p reverse transcriptase. Two recent publications, by Thawani et al. and Baldwin et al., report structures of LINE-1 ORF2p and address long-standing mechanistic gaps regarding LINE-1 retrotransposition. Both studies will be critical to design new specific inhibitors of the LINE-1 ORF2p reverse transcriptase.
Original language | English (US) |
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Pages (from-to) | 286-288 |
Number of pages | 3 |
Journal | Trends in Cancer |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2024 |
Keywords
- LINE-1
- retrotransposition
- retrotransposons
- viral mimicry
ASJC Scopus subject areas
- Oncology
- Cancer Research