TY - JOUR
T1 - Integrated global profiling of cancer
AU - Hanash, Samir
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/8
Y1 - 2004/8
N2 - Tumours are complex biological systems. No single type of molecular approach fully elucidates tumour behaviour, necessitating analysis at multiple levels encompassing genomics and proteomics. Integrated data sets are required to fully determine the contributions of genome alterations, host factors and environmental exposures to tumour growth and progression, as well as the consequences of interactions between malignant or premalignant cells and their microenvironment. The sheer amount and heterogeneous nature of data that need to be collected and integrated are daunting, but effort has already begun to address these obstacles.
AB - Tumours are complex biological systems. No single type of molecular approach fully elucidates tumour behaviour, necessitating analysis at multiple levels encompassing genomics and proteomics. Integrated data sets are required to fully determine the contributions of genome alterations, host factors and environmental exposures to tumour growth and progression, as well as the consequences of interactions between malignant or premalignant cells and their microenvironment. The sheer amount and heterogeneous nature of data that need to be collected and integrated are daunting, but effort has already begun to address these obstacles.
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U2 - 10.1038/nrc1414
DO - 10.1038/nrc1414
M3 - Review article
C2 - 15286743
AN - SCOPUS:3543061612
SN - 1474-175X
VL - 4
SP - 638
EP - 644
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -