Integration of optical devices and nanotechnology for conducting genome research

Pei Yu Chung, Parekh Parag, Zhi Zhu, Claudine Chegini, Gregory Schultz, Weihong Tan, Peng Jiang, Christopher Batich

Research output: Chapter in Book/Report/Conference proceedingConference contribution


SPR based sensing techniques utilize a spectroscopy for transducing biomolecular binding events to variations in spectra. This label-free and real-time technique has widely applied for conducting biomedical research. In this study, we present a spectroscopy-based SPR system for monitoring binding between human serum albumin and nucleic acid library. Compared with conventional SPR technique, this novel system utilizes cost-effective nanostructured arrays and a portable UV-Vis spectrometer. These advantages enable a promising development of a portable analytical device for widespread applications. Meanwhile, multispectral analysis used here also helps increase the sensitivity, and thus transducing the binding event to optical signal efficiently. The result demonstrates that this cost-effective and portable system could be applied for a future application of selecting target aptamer. Moreover, we also present surface enhanced Raman spectroscopy (SERS) on the nanostructured arrays in a label-free approach. This integration of multiple spectroscopy technologies is utilized for conducting genome research efficiently.

Original languageEnglish (US)
Title of host publicationNext-Generation Spectroscopic Technologies IV
StatePublished - 2011
EventNext-Generation Spectroscopic Technologies IV - Orlando, FL, United States
Duration: Apr 25 2011Apr 26 2011

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherNext-Generation Spectroscopic Technologies IV
Country/TerritoryUnited States
CityOrlando, FL


  • Biosensing
  • Label-free
  • Nanopyramid
  • SERS
  • SPR
  • Surface plasmons
  • Templating nanofabrication

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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